{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:07:29Z","timestamp":1790626049738,"version":"4.1.0"},"reference-count":59,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371178"],"award-info":[{"award-number":["32371178"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32501013"],"award-info":[{"award-number":["32501013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471184"],"award-info":[{"award-number":["32471184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Haemodynamic shear stress, sensed by vascular endothelial cells (ECs), is crucial for the functional integrity of ECs and the systemic benefits of exercise. Here, we observed that shear stress triggers the release of medium\/large extracellular vesicles (m\/lEVs), from ECs via activation of the mechanosensitive ion channel Piezo1. Endothelial Piezo1 activation induces Piezo1 translocation to the cell periphery, facilitating its trafficking from the vascular ECs to the smooth muscle cells in the splenic capsule. Within the splenic capsule, the translocated Piezo1 acts as a downstream effector of \u03b11\u2010adrenergic receptor, boosting exercise\u2010induced spleen contraction and enhancing exercise endurance. Genetic or pharmacological inhibition of Piezo1 trafficking from ECs impaired spleen contraction during exercise and reduced exercise endurance in mice. Additionally, exercise\u2010induced m\/lEV release contributes to safeguard endothelial function through modulating intracellular Piezo1 homeostasis. Furthermore, positive correlations between exercise\u2010induced increases in circulating Piezo1\u2010enriched m\/lEVs and the degree of spleen contraction were also observed in human volunteers. These findings unveil a vasculo\u2010splenic axis during exercise, in which EC\u2010derived m\/lEVs shuttle Piezo1 to maintain endothelial function and exercise endurance, highlighting a novel role of Piezo1 in inter\u2010organ communication.<\/jats:p>","DOI":"10.1002\/jev2.70375","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:52:24Z","timestamp":1790625144000},"source":"Crossref","is-referenced-by-count":0,"title":["Shear Stress\u2010Stimulated Trafficking of Endothelial Piezo1 to Splenic Capsule Boosts Spleen Contraction and Exercise Endurance"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6224-8552","authenticated-orcid":false,"given":"Jing","family":"Lou","sequence":"first","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingzong","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Hu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9710-5156","authenticated-orcid":false,"given":"Xuyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"},{"name":"Center for Mitochondrial Biology and Medicine, Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"},{"name":"Department of Ultrasound Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihang","family":"Feng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4611-7194","authenticated-orcid":false,"given":"Yuxin","family":"Xi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-8285","authenticated-orcid":false,"given":"Changyang","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5651-2564","authenticated-orcid":false,"given":"Lijun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Medicine, Tangdu Hospital Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9492-6346","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengpeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6555-1717","authenticated-orcid":false,"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6615-5038","authenticated-orcid":false,"given":"Xing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Aerospace Medicine of the Ministry of Education, School of Aerospace Medicine Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.1016\/j.cell.2024.07.012","article-title":"A Systems View of the Vascular Endothelium in Health and Disease","volume":"187","author":"Augustin H. 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