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This study elucidates the immune mechanisms underlying secondary brain injury following ICH by identifying microglia\u2010derived migrasomes. By integrating immune cell clustering analysis from single\u2010cell RNA sequencing (scRNA\u2010seq) with Mendelian randomization, we identified five key genes associated with ICH. Further experiments revealed that C1qc accumulates around hematomas, worsening blood\u2012brain barrier (BBB) disruption through migrasome\u2010mediated pathways. Our results showed that microglial migrasomes transport C1qc to induce pyroptosis in vascular endothelial cells, thereby compromising BBB integrity. Genetic ablation of C1qc substantially attenuated this BBB damaging effect, C1qc\u2010deficient migrasomes exhibited protective properties. Our findings, for the first time, reveal the mechanistic role of C1qc and migrasomes in ICH pathogenesis and establish microglia\u2010derived migrasomes as promising therapeutic targets, providing novel avenues to improve neurologic outcomes after ICH.<\/jats:p>","DOI":"10.1002\/jev2.70377","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:34:40Z","timestamp":1791430480000},"source":"Crossref","is-referenced-by-count":0,"title":["C1qc Mediates Blood\u2013Brain Barrier Disruption in a Mouse Model of Intracerebral Haemorrhage Through Microglia\u2010Derived Migrasomes"],"prefix":"10.1002","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1789-5261","authenticated-orcid":false,"given":"Mengyuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The First Affiliated Hospital of Zhengzhou University  Zhengzhou Henan 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