{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:08:29Z","timestamp":1790626109144,"version":"4.1.0"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1301500"],"award-info":[{"award-number":["2022YFD1301500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32341053"],"award-info":[{"award-number":["32341053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Extracellular Vesicle"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The gut microbiota plays a critical role in regulating intestinal lipid metabolism, yet the mechanisms governing microbiota\u2013host interactions during lipid uptake remain unclear. Here, we examined the relationship between fat digestibility and gut microbial composition, and found that piglets with higher apparent crude fat digestibility exhibited enhanced lipid absorption and oxidation, accompanied by reduced abundance of\n                    <jats:italic>Clostridium butyricum<\/jats:italic>\n                    in the ileal mucosa. Furthermore, oral administration of\n                    <jats:italic>C. butyricum<\/jats:italic>\n                    suppressed intestinal lipid absorption and oxidation by inhibiting PPAR\u03b1 signaling. Mechanistically, extracellular vesicles (EVs) derived from\n                    <jats:italic>C. butyricum<\/jats:italic>\n                    can enter intestinal epithelial cells and mediate the anti\u2010lipid absorption effects by delivering miRNA\u2010like RNAs (milRNAs), particularly milRNA\u20103020179, which primarily targeted host genes including\n                    <jats:italic>PPAR\u03b1<\/jats:italic>\n                    and\n                    <jats:italic>Rxra<\/jats:italic>\n                    . Supplementation with\n                    <jats:italic>C. butyricum<\/jats:italic>\n                    or its EVs prevented lipid accumulation and attenuated the development of metabolic abnormalities in high\u2010fat diet\u2010fed mice, whereas deletion of milRNA\u20103020179 in\n                    <jats:italic>C. butyricum<\/jats:italic>\n                    abolished its effects on lipid deposition in intestinal organoids. Collectively, these findings identify\n                    <jats:italic>C. butyricum<\/jats:italic>\n                    \u2010derived EV milRNAs as candidate microbial regulators of host lipid metabolism through modulation of PPAR\u03b1 signaling, providing insights into microbiota\u2010driven control of intestinal lipid homeostasis.\n                  <\/jats:p>","DOI":"10.1002\/jev2.70381","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:51:02Z","timestamp":1790625062000},"source":"Crossref","is-referenced-by-count":0,"title":["Extracellular Vesicle\u2010Encapsulated Small RNAs From\n                    <i>Clostridium Butyricum<\/i>\n                    Modulate Host Intestinal Lipid Metabolism"],"prefix":"10.1002","volume":"15","author":[{"given":"Hong","family":"Hu","sequence":"first","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"College of Animal Science and Technology Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"College of Advanced Agricultural Sciences University of Chinese Academy of Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Han","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuqing","family":"Liang","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"College of Bioscience and Biotechnology Hunan Agricultural University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangtian","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Standardisation China Jiliang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Tang","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqin","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation College of Life Sciences Hunan Normal University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulong","family":"Yin","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"College of Advanced Agricultural Sciences University of Chinese Academy of Sciences  Beijing China"},{"name":"Yuelushan Laboratory  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0007-3504","authenticated-orcid":false,"given":"Xihong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Institute of Subtropical Agriculture the Chinese Academy of Sciences  Changsha China"},{"name":"College of Advanced Agricultural Sciences University of Chinese Academy of Sciences  Beijing China"},{"name":"Yuelushan Laboratory  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072148"},{"key":"e_1_2_11_3_1","doi-asserted-by":"crossref","unstructured":"Cardin S. 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M.Borchert.2017. \u201cViral MicroRNAs Host MicroRNAs Regulating Viruses and Bacterial MicroRNA\u2010Like RNAs.\u201dMethods in molecular biology (Clifton N.J.)1617:39\u201356.","DOI":"10.1007\/978-1-4939-7046-9_3"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70250","article-title":"Lachnospiraceae \u2010Derived Extracellular Vesicles Mediate the Cardioprotective Effects of Barley Leaf in Myocardial Infarction by Improving Intestinal Stem Cell Function","volume":"15","author":"Chen W.","year":"2026","journal-title":"Journal of Extracellular Vesicles"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-07835-2"},{"key":"e_1_2_11_6_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114091","article-title":"Molecular Regulators of Lipid Metabolism in the Intestine\u2014Underestimated Therapeutic Targets for Obesity?","volume":"178","author":"D\u00e1valos\u2010Salas M.","year":"2020","journal-title":"Biochemical Pharmacology"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12161","article-title":"Microbiota\u2010Derived Extracellular Vesicles in Interkingdom Communication in the Gut","volume":"10","author":"D\u00edaz\u2010Garrido N.","year":"2021","journal-title":"Journal of Extracellular Vesicles"},{"key":"e_1_2_11_8_1","doi-asserted-by":"crossref","unstructured":"Dong L. 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