{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T21:56:03Z","timestamp":1792014963763,"version":"4.4.0"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["isevjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Extracellular Bio"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Epithelial\u2010mesenchymal transition (EMT) is associated with tumorigenesis and drug resistance. The Rab superfamily of small G\u2010proteins plays a role in regulating cell cytoskeleton and vesicle transport. However, it is not yet clear how the Rab family contributes to cancer progression by participating in EMT. By analysing various in silico datasets, we identified a statistically significant increase in\n                    <jats:italic>RAB31<\/jats:italic>\n                    expression in the oxaliplatin\u2010resistant group compared to that in the parental or other chemotherapy drug groups. Our findings highlight\n                    <jats:italic>RAB31's<\/jats:italic>\n                    powerful effect on colorectal cancer cell lines when compared with other family members. In a study that analysed multiple online meta\u2010databases,\n                    <jats:italic>RAB31<\/jats:italic>\n                    RNA levels were continually detected in colorectal tissue arrays. Additionally,\n                    <jats:italic>RAB31<\/jats:italic>\n                    protein levels were correlated with various clinical parameters in clinical databases and were associated with negative prognoses for patients.\n                    <jats:italic>RAB31<\/jats:italic>\n                    expression levels in all three probes were calculated using a computer algorithm and were found to be positively correlated with EMT scores. The expression of the epithelial\u2010type marker CDH1 was suppressed in\n                    <jats:italic>RAB31<\/jats:italic>\n                    overexpression models, whereas the expression of the mesenchymal\u2010type markers SNAI1 and SNAI2 increased. Notably,\n                    <jats:italic>RAB31<\/jats:italic>\n                    \u2010induced EMT and drug resistance are dependent on extracellular vesicle (EV) secretion. Interactome analysis confirmed that\n                    <jats:italic>RAB31<\/jats:italic>\n                    \/AGR2 axis\u2010mediated exocytosis was responsible for maintaining colorectal cell resistance to oxaliplatin. Our study concluded that\n                    <jats:italic>RAB31<\/jats:italic>\n                    alters the sensitivity of oxaliplatin, a supplementary chemotherapy approach, and is an independent prognostic factor that can be used in the treatment of colorectal cancer.\n                  <\/jats:p>","DOI":"10.1002\/jex2.141","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T23:29:35Z","timestamp":1708730975000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["RAB31 drives extracellular vesicle fusion and cancer\u2010associated fibroblast formation leading to oxaliplatin resistance in colorectal cancer"],"prefix":"10.1002","volume":"3","author":[{"given":"Yu\u2010Chan","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Fang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Education and Research Kaohsiung Veterans General Hospital Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hsiu","family":"Li","sequence":"additional","affiliation":[{"name":"Genomics Research Center Academia Sinica Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Hsien","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Radiological Sciences National Yang Ming Chiao Tung University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng\u2010Lun","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Oncology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Huang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"School of Medicine National Yang Ming Chiao Tung University Taipei Taiwan"},{"name":"Center of Immuno\u2010Oncology, Department of Oncology Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Long","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology Taipei Medical University Hospital, Taipei Medical University Taipei Taiwan"},{"name":"Department of Pathology, College of Medicine Taipei Medical University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8529-9213","authenticated-orcid":false,"given":"Michael","family":"Hsiao","sequence":"additional","affiliation":[{"name":"Genomics Research Center Academia Sinica Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djt371"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541248.2017.1397833"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052622"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-4080"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13378"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-017-0687-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1158\/1538-7445.SABCS19-BS1-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S175502"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2012.1967"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12403"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"D'Adamo P. 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