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Although EVs have been extensively studied in biomedicine, mainly in diagnostic and nanotherapy of cancer and neurodegenerative diseases, their potential\u00a0applications\u00a0in other\u00a0impactful society areas\u00a0are\u00a0only beginning to be explored. Microbial EVs contribute significantly to biofilm formation, virulence and the transmission of antibiotic resistance, highlighting their importance in pathogenicity and infection control. In the aesthetic and dermatological sectors, EVs are gaining traction as innovative agents for skin regeneration, anti\u2010ageing and inflammation modulation, with applications extending to cosmetic dermatology and non\u2010invasive treatments. Veterinary medicine is also exploring EVs for diagnostics and therapeutic delivery, while in agriculture, they show promise in improving crop resilience, acting as natural biopesticides and supporting plant\u2013microbe interactions. Inter\u2010species and interkingdom EV communication understanding, potentially help pest control and disease prevention. Moreover, EVs are being investigated as biosensors for environmental pollution and as agents in soil and water remediation. In the food industry, EVs are explored for their functional benefits in promoting gut and systemic health. However, to fully realize their potential, challenges in large\u2010scale production, quality control and regulatory approval must be addressed. 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