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Although EV research has expanded rapidly, the physiological functions of EVs remain incompletely understood, and coagulation is one of the first biological functions that was attributed to EVs. Since coagulation is a complex balance between coagulation promoting and inhibiting pathways, for clarity and to reduce complexity we focus exclusively on how EVs contribute to coagulation\u2010promoting pathways in physiological conditions. We explain what coagulation is, and how coagulation contributes to haemostasis and host defence, followed by an overview of historical evidence showing that extracellular vesicles initiate and promote coagulation. In addition, we explain how extracellular vesicles provide a coagulation\u2010promoting surface, and expand the classical \u201cenvelope model\u201d. 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