{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T11:43:51Z","timestamp":1759664631931},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,7,19]],"date-time":"2001-07-19T00:00:00Z","timestamp":995500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Francisco Villa Regional System of National Council for Science and Technology of Mexico (CONACyT)","award":["SIVILLA 9502121"],"award-info":[{"award-number":["SIVILLA 9502121"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Establishment of <jats:italic>Entamoeba histolytica<\/jats:italic> infection is facilitated through macrophage effector disruption by a prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>)\u2010mediated mechanism. Infection severity may be measured by weight of abscess formed. Indomethacin (Indo) treatment of infected hamsters reduced abscess weight by 30% at 7 days post\u2010infection presumably by inhibition of PGE<jats:sub>2<\/jats:sub>. To explain reductions in abscess development by Indo treatment, we determined liver functionality in Indo\u2010treated or untreated animals, either healthy or infected. Determinations of serum glutamic oxaloacetic (SGOT) and glutamic pyruvic (SGPT) transaminases, serum alkaline phosphatase (SAP), total serum protein (TSP), and bilirubinemia were done. SGOT, SGPT, and SAP activities showed a significant increase in their values by 600% at seven days post\u2010infection in infected animals in both conditions; nonstatistical differences were found between animals treated or not. This increase did not correlate with the percentage of damage. Infected nontreated hamsters showed TSP levels 30% below normal group (<jats:italic>P<\/jats:italic> &lt; 0.05). Infected Indo\u2010treated hamsters had no significant differences compared to normal values. Infected nontreated animals showed an increase in bilirubin, particularly in indirect bilirubin, whereas infected Indo\u2010treated hamsters showed total bilirubin values lower than normals (<jats:italic>P<\/jats:italic> &lt; 0.05), with a decrease in direct bilirubin levels. Our results demonstrated that <jats:italic>E. histolytica<\/jats:italic> infection in hamsters produces similar abnormalities in liver function as it does in humans, and that the beneficial effect of Indo treatment on amoebic abscess development is not related with an improvement of liver functionality. <jats:italic>J. Exp. Zool. 290:201\u2013206, 2001<\/jats:italic>. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jez.1050","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:49:13Z","timestamp":1030312153000},"page":"201-206","source":"Crossref","is-referenced-by-count":3,"title":["Liver function tests during amoebic liver abscess formation in indomethacin\u2010treated 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