{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:23:17Z","timestamp":1757701397872},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":13880,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1967,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>mi\/mi<\/jats:italic> mouse has a severe microphthalmia, its skeleton shows an almost complete absence of secondary bone resorption, and its eyes and hair have no pigment. The <jats:italic>Mi<jats:sup>wh<\/jats:sup>\/Mi<jats:sup>wh<\/jats:sup><\/jats:italic> mouse is white with a reduced eye size.<\/jats:p><jats:p>The <jats:italic>mi\/mi<\/jats:italic> eye was first distinguished during the tenth day of embryonic development by an abnormally thick pigment layer and a weakly invaginated optic cup. These abnormalities persisted in the older embryos. Normal closure of the mutant choroid fissure was prevented by the inversion of the pigment layer in this region. An eversion of the nervous retina and derangement of the pigment layer were observed in the <jats:italic>Mi<jats:sup>wh<\/jats:sup>\/Mi<jats:sup>wh<\/jats:sup><\/jats:italic> eye during the eleventh day of development. These abnormalities led to the formation of a typical coloboma. Subsequent abnormalities of the <jats:italic>mi\/mi<\/jats:italic> and <jats:italic>Mi<jats:sup>wh<\/jats:sup>\/Mi<jats:sup>wh<\/jats:sup><\/jats:italic> eyes were attributable to the colobomata and the consequent lack of intraocular pressure. Counts of mitoses in the pigment and nervous layers of the optic cups showed that there were increased numbers of mitoses in the pigment layers of both the <jats:italic>mi\/mi<\/jats:italic> and <jats:italic>Mi<jats:sup>wh<\/jats:sup>\/Mi<jats:sup>wh<\/jats:sup><\/jats:italic> eyes.<\/jats:p><jats:p>The <jats:italic>mi\/mi<\/jats:italic> osteoclasts were almost uniformly small and rounded and had significantly fewer nuclei than the large, irregular, multinucleated normal osteoclasts. Osteoclast counts indicated that the mutant parietal bone is not deficient in osteoclasts and may have higher than normal numbers. Mutant osteoclasts were not abnormal in the appearance of their nuclei, frequency of occurrence of cytoplasmic vacuoles, or amount of cytoplasmic basophilia, RNA, or foaminess. While normal osteoclasts contained essentially no glycogen, <jats:italic>mi\/mi<\/jats:italic> osteoclasts contained, as a group, large amounts of glycogen.<\/jats:p>","DOI":"10.1002\/jez.1401650103","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T10:57:58Z","timestamp":1118487478000},"page":"21-45","source":"Crossref","is-referenced-by-count":42,"title":["The eye and skeletal effects of two mutant alleles at the microphthalmia locus of <i>Mus musculus<\/i>"],"prefix":"10.1002","volume":"165","author":[{"given":"Susan O.","family":"Packer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"About Mice and Man: An Introduction to Advanced Biology","author":"Avis F. 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