{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:11:48Z","timestamp":1699834308487},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,17]],"date-time":"2005-05-17T00:00:00Z","timestamp":1116288000000},"content-version":"vor","delay-in-days":13620,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1968,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spleens obtained from the common snapping turtle, <jats:italic>Chelydra serpentina<\/jats:italic> (Linn\u00e9), have been analyzed for immunological competence in several <jats:italic>in vitro<\/jats:italic> systems. Spleen fragments can be maintained in tissue culture for several weeks under conditions permitting antibody formation. Such fragments can produce specific agglutinins to sheep or mouse red blood cells when presented with these antigens <jats:italic>in vitro.<\/jats:italic> Cells obtained from adult turtle spleens can elicit splenomegaly or hepatomegaly <jats:italic>in vitro<\/jats:italic> in a manner suggestive of a graft\u2010versus\u2010host reaction. Using these <jats:italic>in vitro<\/jats:italic> procedures, it has been observed that maturation of the immunological system of the turtle occurs several months after hatching, and that hibernating turtles are defective in immunological capacity. Histological studies indicate that the snapping turtle has cloaca\u2010associated lymphoid tissues similar to the bursa of Fabricius.<\/jats:p>","DOI":"10.1002\/jez.1401670207","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T11:48:05Z","timestamp":1118490485000},"page":"187-196","source":"Crossref","is-referenced-by-count":28,"title":["Tissue culture analysis of immunological capacity of snapping turtles"],"prefix":"10.1002","volume":"167","author":[{"given":"Younan A.","family":"Sidky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Auerbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"615","article-title":"Poikilotherme Wirbeltiere als versuchstiere beim Studium des Wirkungsmechnismus immunologischer Adjuvantien","volume":"12","author":"Ambrosius H.","year":"1964","journal-title":"Acta biol. med. german"},{"key":"e_1_2_1_3_1","first-page":"81","article-title":"Beitr\u00e4ge zur Immunobiologie poikilothermer Wirbeltiere. 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