{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T11:13:36Z","timestamp":1723720416687},"reference-count":8,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T00:00:00Z","timestamp":1115856000000},"content-version":"vor","delay-in-days":12703,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1970,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Testicular teratomas were experimentally produced in mice of strains 129, A\/He, and their F<jats:sub>1<\/jats:sub> hybrids. When male genital ridges from 12\u2010 or 13\u2010day fetuses were grafted to various sites in adults, they developed into testes and some of them had teratomas. When male genital ridges were grafted into sites which descend into the scrotum, (the testis, the epididymis, or the epididymal fat pad of intact or castrate males), they developed into testes most of which contained teratomas. When genital ridges were grafted into sites which do not descend into the scrotum (the kidney, spleen, liver, cryptorchid testis, and ovarian fat pad) they developed into testes and most of them did <jats:italic>not<\/jats:italic> have teratomas. When genital ridges were grafted into intact females or into castrate females injected daily with peanut oil or with a physiological dose of testosterone proprionate, the incidence of teratomas was very low. These results are in accord with the hypothesis that the lower temperature in the scrotum promotes teratocarcinogenesis in grafted genital ridges. None of our results suggest that testicular or ovarian hormones of host origin are involved.<\/jats:p>","DOI":"10.1002\/jez.1401740405","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T23:45:56Z","timestamp":1118533556000},"page":"407-413","source":"Crossref","is-referenced-by-count":15,"title":["Environmental influence on experimental teratocarcinogenesis in testes of mice"],"prefix":"10.1002","volume":"174","author":[{"given":"Leroy C.","family":"Stevens","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091260302"},{"key":"e_1_2_1_3_1","first-page":"99","article-title":"Determination of sex of teratomas derived from early mouse embryos","volume":"44","author":"Dunn G. R.","year":"1970","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_4_1","first-page":"48","article-title":"Abdomino\u2010testicular temperature gradients","volume":"107","author":"Harrison R. G.","year":"1948","journal-title":"J. Physiol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.52.3.654"},{"key":"e_1_2_1_6_1","first-page":"859","article-title":"Development of resistance to teratocarcinogenesis by primordial germ cells in mice","volume":"37","author":"Stevens L. C.","year":"1966","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_7_1","first-page":"549","article-title":"Origin of testicular teratomas from primordial germ cells in mice","volume":"38","author":"Stevens L. C.","year":"1967","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_8_1","first-page":"923","article-title":"Experimental production of testicular teratomas in mice of strains 129, A\/He, and their F1 hybrids","volume":"44","author":"Stevens L. C.","year":"1970","journal-title":"J. Natl. Cancer Inst."},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90130-2"}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1401740405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1401740405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T08:38:29Z","timestamp":1699778309000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1401740405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1970,8]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1970,8]]}},"alternative-id":["10.1002\/jez.1401740405"],"URL":"https:\/\/doi.org\/10.1002\/jez.1401740405","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1970,8]]}}}