{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T03:15:12Z","timestamp":1776136512805,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"vor","delay-in-days":12062,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1972,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Albinism in the leopard frog is due to a recessive gene (<jats:italic>alb<\/jats:italic>) in the homozygous condition. Heterozygous females produce normal, pigmented eggs. After fertilization of these eggs by sperm from another heterozygote, all progeny remain normally pigmented until after hatching when the albino progeny can be detected. Since melanin deposition in oocytes occurs prior to segregation of the <jats:italic>alb<\/jats:italic> and + alleles, the wild\u2010type gene may be transcribed and translated in the oocytes. Alternatively, the product of the + allele may be synthesized exogenously and incorporated into the oocytes during oogenesis.<\/jats:p><jats:p>The results of embryonic transplant experiments suggest that the albino gene is expressed within the neural crest derivatives. Albino hosts support differentiation of wild\u2010type melanophores. Albino dorsal mesoderm induces melanophore differentiation in wild\u2010type neural crest derivatives.<\/jats:p><jats:p>Albinos were less viable than their wild\u2010type siblings in the laboratory environment. Albino larvae developed scoliosis with high frequency, and albino frogs had a higher mortality rate after metamorphosis than their wild\u2010type siblings.<\/jats:p>","DOI":"10.1002\/jez.1401800202","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T05:03:28Z","timestamp":1118552608000},"page":"149-155","source":"Crossref","is-referenced-by-count":17,"title":["Genetic and embryological studies of albinism in <i>Rana pipiens<\/i>"],"prefix":"10.1002","volume":"180","author":[{"given":"Leon W.","family":"Browder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(61)90040-5"},{"key":"e_1_2_1_3_1","unstructured":"Browder L. W.1967Pigmentation inRana pipiens: A study in developmental genetics. Ph.D. thesis. 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