{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T21:38:51Z","timestamp":1766266731354},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,3]],"date-time":"2005-05-03T00:00:00Z","timestamp":1115078400000},"content-version":"vor","delay-in-days":11994,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1972,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The single\u2010active\u2010X hypothesis states that in any mammal with more than one X chromosome per cell, only one X is active in each cell. The hypothesis further states that X\u2010chromosome differentiation occurs randomly in each cell early in development and subsequently is stable. The phenotype of a mammal heterozygous for a sex\u2010linked gene will thus be mosaic, and any interaction of different X alleles can occur only on the intercellular level. Another hypothesis, the \u201ccomplemental\u2010X\u201d hypothesis, explains the phenotype of a sex\u2010linked gene heterozygote in terms of intracellular allelic interaction.<\/jats:p><jats:p>The validity of intercellular interaction in sex\u2010linked gene heterozygotes was tested in the mouse by making fusion chimeras of embryos carrying different X\u2010linked alleles and comparing the chimeric phenotype to that of a standard heterozygote.<\/jats:p><jats:p>The X\u2010chromosome marker <jats:italic>Greasy<\/jats:italic> (Gs) was shown to affect ten parameters of hair structure, four of which were chosen to establish a series of hair types. It was found that <jats:italic>Gs<\/jats:italic>\/ +. mice had almost the entire range of hair types, while wild\u2010type and <jats:italic>Gs<\/jats:italic>\/ mice showed restricted hair type distributions, significantly different from each other and from <jats:italic>Gs<\/jats:italic>\/ +. It was also found that the <jats:italic>Gs<\/jats:italic>\/ + phenotype could not be accounted for by additivity of the wild\u2010type and mutant hair\u2010type distributions.<\/jats:p><jats:p>Some of the fusion chimeras had phenotypes similar, if not identical, to that of standard <jats:italic>Gs<\/jats:italic>\/ + mice in all respects except the rate of change in the distribution of hair types with age. This discrepancy could be accounted for on the basis of cell selection.<\/jats:p><jats:p>These data support the conclusion that intercellular interaction can account for the observed phenotypes of sex\u2010linked gene heterozygotes.<\/jats:p>","DOI":"10.1002\/jez.1401810102","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T05:03:53Z","timestamp":1118552633000},"page":"1-16","source":"Crossref","is-referenced-by-count":4,"title":["Expression of a sex\u2010linked gene in standard and fusion\u2010chimeric mice"],"prefix":"10.1002","volume":"181","author":[{"given":"G. R.","family":"Dunn","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,3]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Methods in Mammalian Embryology","author":"Biggers J. 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