{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:43:11Z","timestamp":1791114191868,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":10928,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1975,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fragments of the wing disc of <jats:italic>Drosophila<\/jats:italic> (fig. 2) were either injected into mature third instar larvae for immediate metamorphosis, or cultured in adult abdomens for seven days before being transferred to larvae for metamorphosis. The structures differentiated during metamorphosis were then analysed. The results of the first series of experiments were used to construct an accurate fate map of the disc, and those of the second series were used to determine the regenerative properties of the disc.<\/jats:p><jats:p>The fate map (fig. 7) shows presumptive proximal parts (notum, pleura, and dorsal and ventral hinge) at the two ends of the disc, with presumptive distal wing parts in between. During metamorphosis the disc epithelium folds upon itself along the presumptive wing border, bringing dorsal and ventral wing and hinge surfaces into apposition. The wing surfaces occupy a much smaller relative area, and the hinge parts a much larger relative area, in the fate map than in the adult structure.<\/jats:p><jats:p>The cultured fragments, in general, behaved in accordance with the rule that when two cut surfaces are created by cutting across the disc, regeneration occurs from one of the cut surfaces and duplication occurs from the other (fig. 14). It was possible to define a level in the longitudinal axis of the disc from which regeneration proceeds outwards. Cut surfaces facing away from this level show regeneration, while cut surfaces facing this level undergo duplication. Similar behavior was found for the transverse axis, and for two diagonal series of cuts.<\/jats:p><jats:p>Some fragments with two cut edges could regenerate from one edge while duplicating from the other, whereas others could regenerate from two cut edges simultaneously. However, fragments with four cut edges showed incomplete regeneration, and a high tendency to duplicate even though regeneration in all directions might have been expected on the basis of the other experiments.<\/jats:p>","DOI":"10.1002\/jez.1401930106","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T09:47:13Z","timestamp":1118483233000},"page":"49-77","source":"Crossref","is-referenced-by-count":281,"title":["Pattern formation in the imaginal wing disc of <i>Drosophila melanogaster<\/i>: Fate map, regeneration and duplication"],"prefix":"10.1002","volume":"193","author":[{"given":"Peter J.","family":"Bryant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"787","article-title":"The development of the legs, wings and halteres in wild\u2010type and some mutant strains of Drosophila melanogaster","volume":"58","author":"Auerbach C.","year":"1936","journal-title":"Trans. roy. Soc. Edinb."},{"key":"e_1_2_1_3_1","unstructured":"Bownes M.Adult deficiencies and duplications of head and thoracic structures resulting from microcautery of blastoderm stageDrosophilaembryos.J. Embryol. exp. Morphol. (in press)."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90160-0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(71)90146-1"},{"key":"e_1_2_1_6_1","first-page":"41","volume-title":"Current Topics in Developmental Biology","author":"Bryant P. J.","year":"1974"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720110.ch5"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050470105"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/280658"},{"key":"e_1_2_1_10_1","volume-title":"Biology ofDrosophila","author":"Ferris G. F.","year":"1965"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00383486"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(71)90047-9"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/newbio245251a0","article-title":"Developmental compartmentalization of the wing disc of Drosophila","volume":"245","author":"Garcia\u2010Bellido A.","year":"1973","journal-title":"Nature New Biol."},{"key":"e_1_2_1_14_1","first-page":"77","article-title":"Ubertragung und Anderung der Determinationsqualitaten in Antennenscheiben\u2010Kulturen von Drosophila melanogaster","volume":"15","author":"Gehring W.","year":"1966","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_15_1","first-page":"35","volume-title":"Results and Problems in Cell Differentiation","author":"Gehring W.","year":"1972"},{"key":"e_1_2_1_16_1","first-page":"211","volume-title":"Developmental Systems: Insects","author":"Gehring W.","year":"1973"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(63)90146-5"},{"key":"e_1_2_1_18_1","first-page":"85","article-title":"Dynamics of determination","volume":"25","author":"Hadorn E.","year":"1966","journal-title":"Symp. Soc. Develop. Biol."},{"key":"e_1_2_1_19_1","first-page":"302","article-title":"\u00dcber Entwicklungsleistungen transplantierter Teilst\u00fccke von Fl\u00fcgel\u2010Imaginalscheiben von Drosophila melanogaster","volume":"69","author":"Hadorn E.","year":"1962","journal-title":"Rev. Suisse Zool."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(61)90035-5"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401790105"},{"key":"e_1_2_1_22_1","first-page":"102","article-title":"Replacement patterns of homoeotic wing structures in halteres","volume":"50","author":"Ouweneel W. J.","year":"1973","journal-title":"Drosoph. Inform. Service"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00576938"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00576805"},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(73)90246-7"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00575521"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00582553"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00573645"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(71)90127-8"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.5479\/si.00963801.36-1687.511"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1163\/002829670X00295"},{"key":"e_1_2_1_32_1","first-page":"291","article-title":"A detailed organ map of the wing disk of Calliphora erythrocephala","volume":"24","author":"Spreij Th. E.","year":"1974","journal-title":"Neth. J. Zool."},{"key":"e_1_2_1_33_1","first-page":"609","article-title":"Zellspezifische Determination und Beziehung zwischen Proliferation und Transdetermination in Bein\u2010 und Flugelprimordien von Drosophila melanogaster","volume":"16","author":"Tobler H.","year":"1966","journal-title":"J. Embryol. exp. Morphol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02569026"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00573357"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.69.10.2812"},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00579124"},{"key":"e_1_2_1_38_1","first-page":"223","article-title":"Zur labilen Determination der Imaginalscheiben von Drosophila. I. Verhalten verschiedenaltriger Imaginalanlagen bei operativer Defektsetzung","volume":"65","author":"Vogt M.","year":"1946","journal-title":"Biol. Zentralbl."},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982977"},{"key":"e_1_2_1_40_1","first-page":"188","volume-title":"Current Topics in Developmental Biology","author":"Wolpert L.","year":"1972"},{"key":"e_1_2_1_41_1","first-page":"17","article-title":"Anatomie du thorax de Drosophila melanogaster","volume":"54","author":"Zalokar M.","year":"1947","journal-title":"Rev. Suisse Zool."},{"key":"e_1_2_1_42_1","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1093\/genetics\/27.6.641","article-title":"The development of dominant rumplessness in chick embryos","volume":"27","author":"Zwilling E.","year":"1942","journal-title":"Genetics"}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1401930106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1401930106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T12:21:56Z","timestamp":1699791716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1401930106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1975,7]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1975,7]]}},"alternative-id":["10.1002\/jez.1401930106"],"URL":"https:\/\/doi.org\/10.1002\/jez.1401930106","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1975,7]]}}}