{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T20:21:13Z","timestamp":1702585273289},"reference-count":4,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,4,25]],"date-time":"2005-04-25T00:00:00Z","timestamp":1114387200000},"content-version":"vor","delay-in-days":10037,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1977,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Three mutant genes, <jats:italic>st<\/jats:italic>, <jats:italic>mi<\/jats:italic>, and <jats:italic>h<\/jats:italic>, were discovered in an axolotl male received from Mexico City. All three are recessive to their normal alleles, and appear to segregate independently.<\/jats:p><jats:p>Larvae homozygous for <jats:italic>st<\/jats:italic> (for <jats:italic>stasis<\/jats:italic>) suffer blockage of the circulation at hatching or shortly after, and the majority soon die; any surviving live only a few weeks at most. The <jats:italic>mi<\/jats:italic>\/<jats:italic>mi<\/jats:italic> (<jats:italic>microphthalmic<\/jats:italic>) can be identified at the feeding stage. None survives more than a few days. The <jats:italic>h<\/jats:italic>\/<jats:italic>h<\/jats:italic> (<jats:italic>hand lethals<\/jats:italic>) live until the digits have appeared on the forelimb. They may then be recognized by the thumb\u2010like orientation of digit 1.<\/jats:p><jats:p>Transplants from <jats:italic>st<\/jats:italic>\/<jats:italic>st<\/jats:italic> embryos into normal produce normal structures which persist indefinitely. Those from <jats:italic>mi<\/jats:italic>\/<jats:italic>mi<\/jats:italic> and <jats:italic>h<\/jats:italic>\/<jats:italic>h<\/jats:italic> donors do not survive. The structures (forelimb, gills) derived from <jats:italic>h<\/jats:italic>\/<jats:italic>h<\/jats:italic> donors grow for a relatively long time, and their final death and degeneration result in defects leading to death of most of the recipients.<\/jats:p><jats:p>Parabiosis is of no benefit to <jats:italic>st<\/jats:italic>\/<jats:italic>st<\/jats:italic> or <jats:italic>h<\/jats:italic>\/<jats:italic>h<\/jats:italic> mutants and leads to the death of the normal twin; <jats:italic>mi<\/jats:italic>\/<jats:italic>mi<\/jats:italic> mutants undergo a gradual absorption by the normal twin.<\/jats:p>","DOI":"10.1002\/jez.1402020208","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T11:00:13Z","timestamp":1118487613000},"page":"195-202","source":"Crossref","is-referenced-by-count":3,"title":["Genetic and experimental studies on three associated mutant genes in the Mexican axolotl: <i>st<\/i> (for stasis), <i>mi<\/i> (for microphthalmic) and <i>h<\/i> (for hand lethal),"],"prefix":"10.1002","volume":"202","author":[{"given":"R. R.","family":"Humphrey","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hae\u2010Moon","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,25]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"169","volume-title":"Developmental Genetics of the Axolotl","author":"Briggs R.","year":"1973"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4613-4470-4_1"},{"key":"e_1_2_1_4_1","first-page":"138","article-title":"Experimental studies on two mutant genes, r and x, in the Mexican axolotl (Ambystoma mexicanum)","volume":"61","author":"Humphrey R. R.","year":"1977","journal-title":"Developmental Biology"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90006-0"}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1402020208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1402020208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T07:32:48Z","timestamp":1699774368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1402020208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,11]]},"references-count":4,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,11]]}},"alternative-id":["10.1002\/jez.1402020208"],"URL":"https:\/\/doi.org\/10.1002\/jez.1402020208","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1977,11]]}}}