{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T00:02:50Z","timestamp":1699833770679},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,5,23]],"date-time":"2005-05-23T00:00:00Z","timestamp":1116806400000},"content-version":"vor","delay-in-days":9853,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1978,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Preimplantation embryos from matings between yellow heterozygous (A<jats:sup>y<\/jats:sup>\/a) mice were recovered at 56 hours <jats:italic>post coitum<\/jats:italic>, cultured for five days, and compared with the development of embryos from three control matings (A<jats:sup>y<\/jats:sup>\/a \u2640 \u00d7 a\/a \u2642, a\/a \u2640 \u00d7 A<jats:sup>y<\/jats:sup>\/a \u2642, a\/a \u2640 \u00d7 a\/a \u2642). Most embryos were at the 8\u2010cell stage at recovery; however fewer embryos from the experimental cross had developed to the 8\u2010cell stage than embryos of control matings, indicating a developmental lag of experimental embryos (P &lt; 0.01). The yellow (A<jats:sup>y<\/jats:sup>\/a) uterus did not contribute (P = 0.05) to delayed development. Experimental and control embryos were equally capable of successful development in culture to the morula stage with no distinct morphological characteristics identifying the class of A<jats:sup>y<\/jats:sup>\/A<jats:sup>y<\/jats:sup> mutants. However, significant differences were observed in the development from morulae to blastocysts; 9.4% (10\/106) of the morulae in experimental crosses failed to undergo blastocyst formation as compared with 2.5% (10\/398) of morulae in pooled control crosses (P = 0.010\u20130.025). In the experimental cross 25.0% (24\/96) of embryos that developed successfully to the blastocyst stage failed to hatch from the zona pellucida; these are presumed to include the class of lethal yellow homozygotes. Abnormalities seen in cultured embryos consisted primarily of blastomere disintegration, blastomere arrest and exclusion, and embryo fragmentation.<\/jats:p>","DOI":"10.1002\/jez.1402040309","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T12:45:54Z","timestamp":1118493954000},"page":"381-389","source":"Crossref","is-referenced-by-count":6,"title":["In vitro analysis of pre\u2010 and early postimplantation development of lethal yellow (A<sup>y<\/sup>\/A<sup>y<\/sup>) mouse embryos"],"prefix":"10.1002","volume":"204","author":[{"given":"Linda L.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nels H.","family":"Granholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,23]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"73","article-title":"Ultrastructural observations of lethal yellow (Ay\/Ay) mouse embryos","volume":"35","author":"Calarco P. G.","year":"1976","journal-title":"J. Embryol. exp. Morph."},{"key":"e_1_2_1_3_1","unstructured":"Cizadlo G. R.1976Physiologic and Embryologic Studies of the Yellow (Ay\/a) Mouse. Ph.D. Dissertation. South Dakota State University. Brookings South Dakota."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00127504"},{"key":"e_1_2_1_5_1","first-page":"157","article-title":"Mating characteristics and embryonic losses in the yellow (Ay\/a) mouse","volume":"54","author":"Cizadlo G. R.","year":"1975","journal-title":"Proc. S. D. Acad. Sci."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02324477"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01664187"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/279647"},{"key":"e_1_2_1_9_1","unstructured":"Johnson L. L.1977In vitrodevelopment of pre\u2010 and early post\u2010implantation lethal yellow (Ay\/Ay) mouse embryos. M.S. Thesis. South Dakota State University Brookings South Dakota."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400280202"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401880307"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720226.ch8"},{"key":"e_1_2_1_13_1","volume-title":"Methods in Experimental Embryology of the Mouse","author":"Rafferty K. A.","year":"1970"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400890203"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/oxfordjournals.jhered.a107450","article-title":"Decreased survival of embryos in yellow (Ay\/a) female mice","volume":"57","author":"Wolff G. L.","year":"1966","journal-title":"J. Heredity."}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1402040309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1402040309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T07:24:36Z","timestamp":1699773876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1402040309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,6]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1978,6]]}},"alternative-id":["10.1002\/jez.1402040309"],"URL":"https:\/\/doi.org\/10.1002\/jez.1402040309","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1978,6]]}}}