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Our experiments showed that in isolated antimycin A plus cyanide treated mitochondria: (a) Ca<jats:sup>++<\/jats:sup> uptake was promoted by electron transport generated by fumarate\u2010dependent oxidation of NADH, (b) Ca<jats:sup>++<\/jats:sup> stimulated fumarate\u2010dependent oxidation of NADH, (c) the ratio of Ca<jats:sup>++<\/jats:sup> uptake:NADH oxidized was 1.7 and (d) the Ca<jats:sup>++<\/jats:sup> sequestered is transiently highly mobile and is rapidly released upon collapse of the membrane potential. In anaerobic hearts perfused with glucose plus fumarate, malate and glutamate Ca<jats:sup>++<\/jats:sup> levels were the same as those in oxygenated hearts while in anaerobic organs perfused with or without glucose Ca<jats:sup>++<\/jats:sup> content was appreciably lower. Succinate production in anaerobic heart perfusions was related to: (a) an increased retention of Ca<jats:sup>++<\/jats:sup> by the heart, (b) a diminution in peak aortic pressure generated by cardiac contractions and (c) an increase in heart rate. The information obtained indicates that mitochondria have a capability for Ca<jats:sup>++<\/jats:sup> movement which might be used physiologically, particularly in fumarate perfused anaerobic hearts, to assist the mechanism for contraction and relaxation of the heart.<\/jats:p>","DOI":"10.1002\/jez.1402070302","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T04:32:31Z","timestamp":1118464351000},"page":"337-350","source":"Crossref","is-referenced-by-count":14,"title":["Anaerobic rat heart: Mitochondrial role in calcium uptake and contractility"],"prefix":"10.1002","volume":"207","author":[{"given":"Howard G.","family":"Shertzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Cascarano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,16]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1976.tb10703.x"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1016\/S0021-9258(18)99724-3","article-title":"Stoichiometric relationships in mitochondrial accumulation of calcium and phosphate supported by hydrolysis of adenosine triphosphate","volume":"241","author":"Bielawski J.","year":"1966","journal-title":"J. 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