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The levels of splenic PFC were significantly depressed following PHZ\u2010induced erythroid differentiation. Although this immune depression may reflect competition at the stem cell levels, whereby pluripotent stem cells (CFU\u2010s) are preferentially differentiated into the erythroid line at the expense of lymphopoietic pathways, other possibilities cannot be excluded. In this regard, we have shown that loading of the mononuclear phagocyte system (MPS) by PHZ\u2010damaged erythrocytes effected profound depressions in splenic PFC numbers. Lastly, in addition to the well\u2010documented increases in CFU\u2010s migration from marrow to spleen during enhanced erythropoiesis, we noted increased migration of B lymphocytes (as assessed by PFC) in marrow\u2010shielded lethally\u2010irradiated mice given PHZ. We also provide data which show that PHZ\u2010damaged RBC evoke increased migration of CFU\u2010s in normal mice, indicating a possible involvement of the MPS in stem cell migration.<\/jats:p>","DOI":"10.1002\/jez.1402130206","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T00:31:24Z","timestamp":1118536284000},"page":"199-203","source":"Crossref","is-referenced-by-count":4,"title":["Splenic plaque\u2010forming cells (PFC) and stem cells (CFU\u2010s) during acute phenylhydrazine\u2010induced enhanced erythropoiesis"],"prefix":"10.1002","volume":"213","author":[{"given":"V. A.","family":"Kozlov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. N.","family":"Zhuravkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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