{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T20:26:35Z","timestamp":1769286395558,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":8886,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1981,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The degree of differentiation of two types of hereditary melanomas of interspecific hybrids between the spotted variety of the platyfish (<jats:italic>Xiphophorus maculatus<\/jats:italic>) and the swordtail (<jats:italic>Xiphophorus helleri<\/jats:italic>) was examined electron microscopically. Melanomas of the fry consisted mainly of pigmented cells containing intermediately matured melanosomes and few other cytoplasmic structures. Melanomas of the adult consisted of lightly pigmented cells having a small number of immature melanosomes; numerous polysomes; well\u2010developed, rough\u2010surfaced endoplasmic reticulum (RER) and Golgi systems; and irregularly shaped nuclei. Thus the fry and adult melanomas appear to represent relatively well\u2010 and poorly differentiated states of fish melanophores, respectively. Amela\u2010notic melanomas in the adult melanotic F<jats:sub>1<\/jats:sub> generation were also characterized. Virus\u2010like particles were often found in the nuclei of both melanotic and amelanotic melanoma cells in the adult fish.<\/jats:p>","DOI":"10.1002\/jez.1402150202","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T08:14:52Z","timestamp":1118477692000},"page":"133-142","source":"Crossref","is-referenced-by-count":11,"title":["Differentiation of melanomas occurring in platyfish\u2010swordtail hybrids of different ages: An ultrastructural study"],"prefix":"10.1002","volume":"215","author":[{"given":"Takashi","family":"Esaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Asada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Wakamatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Ozato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"103","volume-title":"Recent Advances in Cancer Research: Cell Biology, Molecular Biology and Tumor Virology","author":"Ahuja M. 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