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In addition, these embryos had a delay of the normal episode of cell death in the preaxial apical ectodermal ridge and an absence of cell death in a zone of physiological necrosis in the preaxial mesoderm thought to be instrumental in controlling preaxial digit formation. The role of cell death in the pathogenesis of polydactyly is discussed.<\/jats:p>","DOI":"10.1002\/jez.1402160111","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T10:51:12Z","timestamp":1118487072000},"page":"107-112","source":"Crossref","is-referenced-by-count":46,"title":["Aspirin\u2010induced teratogenesis: A unique pattern of cell death and subsequent polydactyly in the rat"],"prefix":"10.1002","volume":"216","author":[{"given":"Kenneth L.","family":"Klein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,5,13]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"255","volume-title":"Organogenesis","author":"Amprino R.","year":"1965"},{"key":"e_1_2_1_3_1","first-page":"155","article-title":"The function of the ectodermal ridge and distinctive characteristics of adjacent distal mesoderm in the avian wing bud","volume":"34","author":"Cairns J. 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