{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:00:40Z","timestamp":1697896840562},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":8493,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1982,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The white allele <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic> of the microphthalmia locus, when homozygous, causes a complete absence of neural crest\u2010derived melanocytes in skin and internal organs. The site(s) of gene action of <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic> on melanoblast differentiation were examined by making dermal\u2010epidermal recombinant grafts with skin from 13\u201314\u2010day embryos of the following genotypes: normal (+\/+), heterozygous white (<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/+), homozygous white (<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>), and dominant spotting (<jats:italic>W<\/jats:italic>\/<jats:italic>W<\/jats:italic>). Based on results from these grafts, the following conclusions were reached: <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic> epidermis is as effective as <jats:italic>W<\/jats:italic>\/<jats:italic>W<\/jats:italic> epidermis in supporting the differentiation of +\/+ follicular melanocytes. <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic> dermis is completely permissive to in situ differentiation of +\/+ follicular melanocytes. Thirteen\u2010fourteen\u2010day embryonic <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic> skin, both epidermis and dermis, alters or blocks the differentiation of +\/+ melanoblasts into dermal melanocytes. By 13 days of development, melanoblasts from both <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/+ and <jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic> skin, even when presented with a permissive <jats:italic>W<\/jats:italic>\/<jats:italic>W<\/jats:italic> environment, are irreversibly redirected into abnormal developmental pathways resulting in either a reduction in follicular pigmentation (<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/+) or a complete absence of follicular melanocytes (<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>\/<jats:italic>Mi<jats:sup>wh<\/jats:sup><\/jats:italic>).<\/jats:p>","DOI":"10.1002\/jez.1402200112","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T08:40:20Z","timestamp":1118479220000},"page":"93-101","source":"Crossref","is-referenced-by-count":5,"title":["Site of gene action of the white allele (<i>Mi<sup>wh<\/sup><\/i>) of the microphthalmia locus: A dermal\u2010epidermal recombination study"],"prefix":"10.1002","volume":"220","author":[{"given":"Bruce M.","family":"Pratt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(62)90337-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.1970.0019"},{"key":"e_1_2_1_4_1","first-page":"123","article-title":"Spotting genes and internal pigmentation patterns in the mouse","volume":"26","author":"Deol M. S.","year":"1971","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_5_1","first-page":"483","article-title":"The role of the tissue environment in the expression of spotting genes in the mouse","volume":"30","author":"Deol M. S.","year":"1973","journal-title":"J. Embryol. Exp. Morph."},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/oxfordjournals.jhered.a105681","article-title":"Mutant white mice: A new dominant autosomal mutant affecting coat color in Mus musculus","volume":"38","author":"Grobman A. B.","year":"1947","journal-title":"J. Hered."},{"key":"e_1_2_1_7_1","first-page":"65","article-title":"Interallelic complementation of microphthalmia and white genes in mice","volume":"4","author":"Konyukhov B. V.","year":"1968","journal-title":"Genetika"},{"key":"e_1_2_1_8_1","first-page":"100","article-title":"Damage of derivatives of neural crest in mice of mutant lines Microphthlamia and White","volume":"8","author":"Konyukhov B. V.","year":"1965","journal-title":"Arch. Anat. Histol. Embryol."},{"key":"e_1_2_1_9_1","first-page":"31","volume-title":"Current Topics in Developmental Biology","author":"LeDouarin N.","year":"1980"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/genetics\/41.3.429","article-title":"The effects of genotype and cell environment on melanoblast differentiation in the house mouse","volume":"41","author":"Markert C. L.","year":"1956","journal-title":"Genetics"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(65)90042-4"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(67)90051-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401660312"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(70)90100-4"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401840308"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(73)90337-0"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90268-8"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402100109"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/genetics\/71.2.297","article-title":"Mesoderm\u2010ectoderm interaction in the production of the agouti pigmentation pattern in mice","volume":"71","author":"Mayer T. C.","year":"1972","journal-title":"Genetics"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(68)90023-7"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402020311"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-0-12-611909-1.50006-0","volume-title":"Control Mechanisms in the Expression of Cellular Phenotypes","author":"Mintz B.","year":"1970"},{"key":"e_1_2_1_23_1","first-page":"345","volume-title":"Control Mechanisms of Growth and Differentiation","author":"Mintz B.","year":"1971"},{"key":"e_1_2_1_24_1","first-page":"292","article-title":"Inhibition of the migration of ectomesenchyme by the White (Miwh\n                  ) gene in mice","volume":"4","author":"Osipov V. V.","year":"1973","journal-title":"Soviet J. Develop. Biol."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401650103"},{"key":"e_1_2_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(74)90204-8"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(75)90329-2"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90422-4"},{"key":"e_1_2_1_29_1","unstructured":"Pratt B. M.(1979)An analysis of the phenotype and gene action of Microphthalmic White (Miwh)in the house mouse. Ph. D. Thesis Michigan State University."},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-99906-2_27"},{"key":"e_1_2_1_31_1","unstructured":"Rittenhouse E. W.(1965)Inherited variation in the fine structure of melanin granules in hair bulbs melanocytes of the house mouse. Ph. D. Thesis University of Michigan."},{"key":"e_1_2_1_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1401720205"},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(76)90132-9"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050990103"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091300202"},{"key":"e_1_2_1_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-6164-3"}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1402200112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1402200112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T02:58:05Z","timestamp":1697684285000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1402200112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1982,3]]}},"alternative-id":["10.1002\/jez.1402200112"],"URL":"https:\/\/doi.org\/10.1002\/jez.1402200112","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,3]]}}}