{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T09:31:34Z","timestamp":1762075894660},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,20]],"date-time":"2005-05-20T00:00:00Z","timestamp":1116547200000},"content-version":"vor","delay-in-days":8197,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1982,12,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The effect of partially purified chinook salmon gonadotropin (SG\u2010G100) and a number of steroids on the induction of germinal vesicle breakdown (GVBD) in amago salmon (<jats:italic>Oncorhynchus rhodurus<\/jats:italic>) oocytes (with intact follicle layers) was investigated in vitro. SG\u2010G100 was effective only at the highest concentration tested (1 \u03bcg\/ml). 17\u03b1,20\u03b2\u2010Dihydroxy\u20104\u2010pregnen\u20103\u2010one (17\u03b1,20\u03b2\u2010diOHprog) was the most potent maturation\u2010inducing steroid tested, followed by 17\u03b1\u2010hydroxyprogesterone. Testosterone or deoxycorticosterone (DOC) enhanced the rate of GVBD in response to SG\u2010G100. DOC also enhanced the response to 17\u03b1,20\u03b2\u2010diOHprog but testosterone was without effect, suggesting that DOC has a direct action on the oocyte while testosterone probably acts at the level of the follicle. Estradiol\u201017\u03b2 had no effect on GVBD in response to SG\u2010G100 or 17\u03b1,20\u03b2\u2010diOHprog.<\/jats:p><jats:p>The action of SG\u2010G100 was shown to be dependent on the synthesis of a second \u0394<jats:sup>4<\/jats:sup> steroidal mediator of maturation since cyanoketone, a specific inhibitor of 3\u03b2\u2010hydroxy\u2010\u0394<jats:sup>5<\/jats:sup>\u2010steroid dehydrogenase, completely abolished the maturational effects of the gonadotropin and pregnenolone but not \u0394<jats:sup>4<\/jats:sup> steroids. Radioimmunoassay of media in which oocytes were induced to mature in vitro with SG\u2010G100 revealed significantly elevated levels of progesterone and 17\u03b1,20\u03b2\u2010diOHprog. Estradiol\u201017\u03b2 levels, high in control media, were only elevated twofold by SG\u2010G100. Levels of the two progestogens were extremely low or nondetectable in media in which oocytes were incubated with cyanoketone, while estradiol\u201017\u03b2 levels remained high. These results are discussed in relation to other evidence indicating that 17\u03b1,20\u03b2\u2010diOHprog is the naturally occurring maturation\u2010inducing steroid of amago salmon. The role of other steroid hormones, particularly the possible involvement of corticosteroids, in the control of final oocyte maturation in teleosts is explored.<\/jats:p>","DOI":"10.1002\/jez.1402240217","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T12:49:00Z","timestamp":1118494140000},"page":"265-275","source":"Crossref","is-referenced-by-count":67,"title":["Oocyte maturation in the amago salmon (<i>Oncorhynchus rhodurus<\/i>): In vitro effects of salmon gonadotropin, steroids, and cyanoketone (an inhibitor of 3\u03b2\u2010hydroxy\u2010\u0394<sup>5<\/sup>\u2010steroid dehydrogenase)"],"prefix":"10.1002","volume":"224","author":[{"given":"Graham","family":"Young","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Kagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Nagahama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,20]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"375","article-title":"Disorders of adrenal steroid biogenesis","volume":"23","author":"Bongiovanni A. 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