{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T06:38:45Z","timestamp":1720075125855},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":8187,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Specimens of <jats:italic>Triturus cristatus carnifex<\/jats:italic> (Laurenti) raised for about 3 weeks in a 3 gm\/liter solution of sodium lactate present a slight alkalosis and a mean increase of about 35% in the red blood cell count in comparison to control animals raised in identically oxygenated water; analogous treatment with an equal molar concentration of sodium pyruvate produces only alkalosis. Since lactate alone determines an increase in the number of erythrocytes as does hypoxia, and hypoxia always induces an increase in plasma lactate levels, it can be deduced that erythropoietin (ESF) production is stimulated by an increase in plasma lactate and not directly by a lack of oxygen. The hypothesis that ESF in newts is produced by the \u201clactate\u2010sensitive cells\u201d of the renal corpuscles, which hypertrophy after experimental anaemia or treatment with lactic acid salts, is indirectly confirmed.<\/jats:p>","DOI":"10.1002\/jez.1402250102","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T02:29:31Z","timestamp":1118456971000},"page":"1-4","source":"Crossref","is-referenced-by-count":3,"title":["J10 lactate\u2010induced polycythemia in newts"],"prefix":"10.1002","volume":"225","author":[{"given":"Giuliano","family":"Frangioni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianfranco","family":"Borgioli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2307\/1440059"},{"key":"e_1_2_1_3_1","first-page":"367","article-title":"Il sangue di. Triturus cristatus carnifex (Laur.) nei maschi e nelle femmine. Gli elementi figurati, il valore ematocritico e il contenuto in emoglobina","volume":"7","author":"Della Corte F.","year":"1961","journal-title":"Atti Soc. Peloritana Sci. Fis. Mat. Nat."},{"key":"e_1_2_1_4_1","first-page":"459","article-title":"Erythropoietin: Pharmacology, biogenesis and control of production","volume":"24","author":"Fisher J. W.","year":"1972","journal-title":"Pharmacol. Rev."},{"key":"e_1_2_1_5_1","first-page":"617","article-title":"Ricerca comparativa sull'anemia sperimentale da acetil\u2010fenil\u2010idrazina (A. F. I.) e monossido di carbonio (CO) in Triturus cristatus carnifex","volume":"39","author":"Frangioni G.","year":"1972","journal-title":"Boll. Zool."},{"key":"e_1_2_1_6_1","first-page":"181","article-title":"The fundamental role of lactate in erythropoiesis: Experimental studies on larvae of Amphibia Anura","volume":"12","author":"Frangioni G.","year":"1978","journal-title":"Monitore Zool. Ital. (NS)"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00237808"},{"key":"e_1_2_1_8_1","first-page":"1039","article-title":"Anemia sperimentale in Triturus cristatus carnifex","volume":"48","author":"Frangioni G.","year":"1972","journal-title":"Boll. Soc. Ital. Biol. Sper."},{"key":"e_1_2_1_9_1","first-page":"25","article-title":"Demostration of the presence of macula densa in the nephrons of the newt by stimulation with sodium lactate. The problem of its physiological role","volume":"13","author":"Frangioni G.","year":"1979","journal-title":"Monitore Zool. Ital. (NS)"},{"key":"e_1_2_1_10_1","first-page":"533","article-title":"Calcium and ionophore A\u201023187 as initiators of DNA replication in the pluripotent haemopoietic stem cell","volume":"9","author":"Gallien\u2010Lartigue O.","year":"1976","journal-title":"Cell Tissue Kinet."},{"key":"e_1_2_1_11_1","first-page":"141","volume-title":"Renal Pharmacology","author":"Gordon A.","year":"1971"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1242\/jcs.12.2.463","article-title":"Erythropoiesis in the newt, Triturus cristatus Laur. I. Identification of the \u201cerythroid precursor cell","volume":"12","author":"Grasso J. A.","year":"1973","journal-title":"J. Cell Sci."},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1242\/jcs.12.2.491","article-title":"Erythropoiesis in the newt. Triturus cristatus Laur. II. Characteristics of the erythropoietic process","volume":"12","author":"Grasso J. A.","year":"1973","journal-title":"J. Cell Sci."},{"key":"e_1_2_1_14_1","volume-title":"The Red Cell: Production, Metabolism, Destruction: Normal and Abnormal","author":"Harris J.","year":"1972"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.2307\/1440807"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI103605"},{"key":"e_1_2_1_17_1","volume-title":"Erythropoietin and the Regulation of Erythropoiesis","author":"Krantz S.","year":"1970"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197304052881404"},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1182\/blood.V44.3.339.339","article-title":"Mechanism of erythropoietin production by cobaltous chloride","volume":"44","author":"Miller M. E.","year":"1974","journal-title":"Blood"},{"key":"e_1_2_1_20_1","first-page":"89","article-title":"Kidney: An organ of oxygen perception","volume":"20","author":"Necas E.","year":"1974","journal-title":"Acta Univ. Carol. (Med.)"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-140-36593"},{"key":"e_1_2_1_22_1","first-page":"542","article-title":"Lactate stimulation of renal cortical adenylate cyclase: a mechanism for erythropoietin production following cobalt treatment or hypoxia","volume":"190","author":"Rodgers G. M.","year":"1974","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI101932"},{"key":"e_1_2_1_24_1","first-page":"11","article-title":"The effect of lactic acid on erythropoietin production and the rate of disappearance of erythropoietin from rat plasma during exercise. Life Sci. Part II Biochem","volume":"10","author":"Zivny J.","year":"1971","journal-title":"Gen. Molec. Biol."}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1402250102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1402250102","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T01:08:50Z","timestamp":1697764130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1402250102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/jez.1402250102"],"URL":"https:\/\/doi.org\/10.1002\/jez.1402250102","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}