{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T14:34:12Z","timestamp":1759588452931},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"vor","delay-in-days":7314,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1985,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Treatment of the killifish, <jats:italic>Fundulus heteroclitus<\/jats:italic>, with ovine thyrotropin (oTSH) produced elevations in serum thyroxin (T<jats:sub>4<\/jats:sub>) that varied seasonally with a strong inverse correlation to environmental photoperiod (P &lt; 0.001). At 20\u00b0C, oTSH (0.2 IU) increased serum T<jats:sup>4<\/jats:sup> to levels ranging from 1.5 \u03bcg\/100 ml in midsummer to 7.5 \u03bcg\/100 ml in midwinter despite relatively stable resting levels throughout the two years of study. Similar rates of clearance of T<jats:sub>4<\/jats:sub> in summer and winter suggest that an alteration in thyroid response to oTSH accounts for this change. The serum T<jats:sub>4<\/jats:sub> response to oTSH is both photoperiod\u2010 and temperature\u2010dependent. In laboratory studies, fish exposed to a short artificial photoperiod (LD 8:16) for one month responded to oTSH with T<jats:sub>4<\/jats:sub> levels about twice as high as those in fish exposed to long days (LD 14:10). On the other hand the T<jats:sub>4<\/jats:sub> response to oTSH was sharply reduced at 5\u00b0C from that seen at 20\u00b0C. This suggests that, in nature, seasonal changes in photoperiod and temperature have opposite effects on thyroidal responsiveness to TSH. Overall, the annual variation in the T<jats:sub>4<\/jats:sub> response to oTSH appears to be driven by photoperiod, inasmuch as the alterations preceded major temperature changes in the wild and can be shown to occur at constant temperature in captivity. Photoperiodic induction of changes in thyroid sensitivity may aid in the maintenance of basal T<jats:sub>4<\/jats:sub> levels under changing thermal conditions.<\/jats:p>","DOI":"10.1002\/jez.1402340205","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T06:25:13Z","timestamp":1118471113000},"page":"199-205","source":"Crossref","is-referenced-by-count":17,"title":["Photoperiodic regulation of thyroid responsiveness to TSH in <i>Fundulus heteroclitus<\/i>"],"prefix":"10.1002","volume":"234","author":[{"given":"E. Gordon","family":"Grau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton H.","family":"Stetson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Insect Photoperiodism","author":"Beck S. 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