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When oocytes within preovulatory follicles were preincubated in the presence of FK for 2\u201310 hr, they matured normally after additional incubation for 10\u201320 hr in plain culture medium. Naked (follicle cell\u2010free) oocytes did not mature under these conditions. FK stimulated dose\u2010dependent production of steroids (estradiol\u201017\u03b2, E<jats:sub>2<\/jats:sub>, and 17\u03b1,20\u03b2\u2010dihydroxy\u20104\u2010pregnen\u20103\u2010one, 17\u03b1,20\u03b2\u2010diOHprog) and cAMP in follicle (granulosa) cells. On the other hand, exposure to FK within 2 hr after 17\u03b1,20\u03b2\u2010diOH prog stimulation caused reversible inhibition of gonadotropin (PMS)\u2010 or 17\u03b1,20\u03b2\u2010diOH prog\u2010induced maturation of the intrafollicular oocytes in vitro. FK also significantly inhibited the 17\u03b1,20\u03b2\u2010diOHprog\u2010induced maturation of naked oocytes, suggesting the existence of adenylate cyclase in fish oocytes. These data indicate that in <jats:italic>Oryzias latipes<\/jats:italic>, FK induces oocyte maturation by stimulating follicular production of maturation\u2010inducing steroid (MIS), probably 17\u03b1,20\u03b2\u2010diOH prog, via an increase in cAMP, and that it may inhibit oocyte maturation by increasing ooplasmic cAMP and some inhibitory interaction between the granulosa cells and the oocyte through intercellular communication.<\/jats:p>","DOI":"10.1002\/jez.1402410113","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T02:47:59Z","timestamp":1118458079000},"page":"101-111","source":"Crossref","is-referenced-by-count":32,"title":["Induction and inhibition of in vitro oocyte maturation and production of steroids in fish follicles by forskolin"],"prefix":"10.1002","volume":"241","author":[{"given":"T.","family":"Iwamatsu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. 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