{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T16:36:02Z","timestamp":1758126962282},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":6545,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1987,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tyrosinase activities and dopachrome conversion activity were evaluated in extracts made from skins of 6\u2010day\u2010old mice that were mutant at the agouti and albino loci. Dopa oxidase (DO) activity of tyrosinase in fully pigmented (<jats:italic>C\/C<\/jats:italic>) mice is reduced in extracts made from skins of yellow 6\u2010day\u2010old mice as compared to those of black mice. Dopachrome conversion (DC) activity is absent from skin extracts of normal yellow mice and is present in normal black mice. DC activity is a characteristic of a separate enzyme which has been called dopachrome conversion factor or dopachrome oxidoreductase. We measured the dopa oxidase activity and dopachrome conversion activity in skin extracts of yellow mice and black mice that were mutant at the albino (<jats:italic>C<\/jats:italic>) locus. Extracts made from extreme\u2010dilution (<jats:italic>c<jats:sup>e<\/jats:sup><\/jats:italic>\/<jats:italic>c<jats:sup>e<\/jats:sup><\/jats:italic>) mice do not have DO activity. Those from yellow extreme\u2010dilution mice do not have DC activity, while those from black, extreme\u2010dilution mice do. The DO and DC activities that characterize skin extracts made from platinum (<jats:italic>c<jats:sup>p<\/jats:sup><\/jats:italic>\/<jats:italic>c<jats:sup>p<\/jats:sup><\/jats:italic>) yellow mice are similar to those of platinum black mice. These observations suggest possible mechanisms by which the functions controlled by the agouti and albino loci interact to control melanogenesis.<\/jats:p>","DOI":"10.1002\/jez.1402430110","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T02:58:35Z","timestamp":1118458715000},"page":"71-79","source":"Crossref","is-referenced-by-count":43,"title":["Genetic controls over melanocyte differentiation: Interaction of agouti\u2010locus and albino\u2010locus genetic defects"],"prefix":"10.1002","volume":"243","author":[{"given":"M. Lynn","family":"Lamoreux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phil","family":"Pendergast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12263381"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/oxfordjournals.jhered.a110019","article-title":"Decreased dopachrome oxidoreductase activity in yellow mice","volume":"76","author":"Barber J. R.","year":"1985","journal-title":"J. Hered."},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_1_5_1","volume-title":"Genetics and Probability in Animal Breeding Experiments","author":"Green E. 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C.","year":"1972","journal-title":"Genetics"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(83)90202-6"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(79)58172-5"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12265251"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1016\/S0021-9258(19)67976-7","article-title":"Separation, purification and properties of two tyrosinases from hamster melanoma","volume":"238","author":"Pomerantz S. H.","year":"1963","journal-title":"J. Biol. Chem."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12521344"},{"key":"e_1_2_1_17_1","first-page":"129","volume-title":"Phenotypic Expression in Pigment Cells","author":"Quevedo W. 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