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Treatment with the Ca<jats:sup>2+<\/jats:sup> ionophore A23187 (to elevate intracellular Ca<jats:sup>2+<\/jats:sup>) reduced Cl<jats:sup>\u2212<\/jats:sup> absorption and produced hyperpolarization of the apical membrane potential of intestinal epithelial cells. The Ca<jats:sup>2+<\/jats:sup>\u2010calmodulin antagonists trifluoperazine (TFP) and calmidazolium (R24571) produced opposite effects, i.e., stimulation of Cl<jats:sup>\u2212<\/jats:sup> absorption and cellular depolarization. Treatment with TFP or R24571 will block or override the inhibitory action of A23187. These data suggest a regulatory role for Ca<jats:sup>2+<\/jats:sup> in the control of intestinal NaCl absorption and mediation via calmodulin.<\/jats:p>","DOI":"10.1002\/jez.1402440109","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T12:56:00Z","timestamp":1118494560000},"page":"67-78","source":"Crossref","is-referenced-by-count":9,"title":["Regulation of goby intestinal ion absorption by the calcium messenger system"],"prefix":"10.1002","volume":"244","author":[{"given":"Christopher A.","family":"Loretz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,4,25]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"219","article-title":"Preparation of metal\u2010chelate complexes and the design of steady\u2010state kinetic experiments involving metal nucleotide complexes","volume":"10","author":"Bartfai T.","year":"1979","journal-title":"Adv. Cyclic. Nucl. 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