{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:31:53Z","timestamp":1767843113132,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,9]],"date-time":"2005-05-09T00:00:00Z","timestamp":1115596800000},"content-version":"vor","delay-in-days":5334,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1990,10]]},"abstract":"Abstract<\/jats:title>The goal of this investigation was to evaluate the role of the Y chromosome in spermatogenesis by a quantitative and qualitative analysis of spermatogenesis as it occurs in the absence of a significant portion of the Y chromosome, i.e., in XO,Sxr<\/jats:italic> male mice. Although these mice have the testis\u2010determining portion of the Y chromosome on their single X chromosome, they lack most of the Y chromosome. Since it was found that all sperm\u2010specific structures were assembled in a normal spatial and temporal pattern in spermatids of XO,Sxr<\/jats:italic> mice, the genes controlling these structures cannot be located on the Y chromosome outside of the Sxr<\/jats:italic> region, and are more likely to be on autosomes or on the X chromosome. In spite of the assembly of the correct sperm\u2010specific structures, spermatogenesis was not quantitatively normal in XO,Sxr<\/jats:italic> mice and significantly reduced numbers of spermatids were found in the seminiferous tubules of these mice. Furthermore, two size classes of spermatids were found in the testes of XO,Sxr<\/jats:italic> mice, normal and twice\u2010normal size. These findings are suggestive of abnormalities of meiosis in XO,Sxr<\/jats:italic> spermatocytes, which lack one of the two sex chromosomes, and may not implicate function of specific genes on the Y chromosome. Morphological abnormalities of spermatids, which were not unique to XO,Sxr<\/jats:italic> mice, were observed and these may be due to either a defective testicular environment because of reduced numbers of germ cells or to the lack of critical Y chromosome\u2010encoded products. Since pachytene spermatocytes of XO,Sxr<\/jats:italic> mice exhibited a sex vesicle, it can be concluded that the assembly of this structure does not depend on the presence of either a complete Y chromosome or the pairing partner for the X chromosome.<\/jats:p>","DOI":"10.1002\/jez.1402560112","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T02:06:20Z","timestamp":1118455580000},"page":"92-105","source":"Crossref","is-referenced-by-count":18,"title":["Spermatogenesis in XO,Sxr<\/i> mice: Role of the Y chromosome"],"prefix":"10.1002","volume":"256","author":[{"given":"Mary C.","family":"Kot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Handel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,9]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.101.Supplement.133"},{"key":"e_1_2_1_3_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1242\/dev.102.2.443","article-title":"Cell\u2010autonomous action of the testisdetermining gene: Sertoli cells are exclusively XY in XX \u2194 XY chimaeric mouse testes","volume":"102","author":"Burgoyne P. S.","year":"1988","journal-title":"Development"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/320170a0"},{"key":"e_1_2_1_5_1","first-page":"305","volume-title":"The Early Development of Mammals","author":"Cattanach B. M.","year":"1975"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130151"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00292419"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.20.120186.001551"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1242\/dev.102.2.251","article-title":"Genetics of sex determination in man and mouse","volume":"102","author":"Goodfellow P. N.","year":"1988","journal-title":"Development"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00295026"},{"key":"e_1_2_1_11_1","first-page":"1","volume-title":"Results and Problems in Cell Differentiation, 15 \u201cSpermatogenesis: Genetic Aspects.\u201d","author":"Handel M. A.","year":"1987"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120210409"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1093\/genetics\/101.1.57","article-title":"Defective histone transition during spermatogenesis in heterozygous segregation distorter males of Drosophila melanogaster","volume":"101","author":"Hauschtek\u2010Jungen E.","year":"1982","journal-title":"Genetics"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(77)90222-6"},{"key":"e_1_2_1_15_1","first-page":"327","article-title":"Absence of a sex vesicle in meiotic foetal germ cells is consistent with an XY sex chromosome constitution","volume":"88","author":"Hogg H.","year":"1985","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.1120180107"},{"key":"e_1_2_1_17_1","first-page":"370","volume-title":"Proceedings of the International Symposium on Genetics of the Spermatozoon","author":"Krzanowska H.","year":"1972"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0016672300016864"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1530\/jrf.0.0770265"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132269"},{"key":"e_1_2_1_21_1","first-page":"515","article-title":"A study of meiotic germ cells in the gonads of fetal mouse chimeras","volume":"27","author":"McLaren A.","year":"1972","journal-title":"J. Embryol. Exp. Morphol."},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000130307"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1000990303"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091690305"},{"key":"e_1_2_1_25_1","first-page":"172","article-title":"Partial deletion of the Y chromosome and sperm abnormalities","volume":"80","author":"Styrna J.","year":"1988","journal-title":"Mouse News Lett."},{"key":"e_1_2_1_26_1","unstructured":"Styrna J. H. T.Imai andK.Morikawi(1990) Partial deletion of the Y chromosome reduces the heterosis effect on the sperm head abnormalities in mice.Genet. Res. in press."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00278879"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402280204"}],"container-title":["Journal of Experimental Zoology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.1402560112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.1402560112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T01:18:54Z","timestamp":1698023934000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.1402560112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,10]]},"references-count":27,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,10]]}},"alternative-id":["10.1002\/jez.1402560112"],"URL":"https:\/\/doi.org\/10.1002\/jez.1402560112","archive":["Portico"],"relation":{},"ISSN":["0022-104X","1097-010X"],"issn-type":[{"value":"0022-104X","type":"print"},{"value":"1097-010X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,10]]}}}