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A number of genes with striking homology to the <jats:italic>Drosophila<\/jats:italic> homeobox genes have now been found in the mouse genome, and mutational analysis is beginning to shed light on their function in mammalian development. To understand better the developmental significance of the murine <jats:italic>Hox\u20102.2<\/jats:italic> gene, we have generated gain of function mutants by using the chicken \u03b2\u2010actin promoter to drive ubiquitous expression in transgenic mice. The resulting <jats:italic>Hox\u20102.2<\/jats:italic> misexpression produces early postnatal lethality as well as craniofacial and axial skeletal perturbations that include open eyes at birth, cleft palate, micrognathia, microtia, skull bone deficiencies, and structural and positional alterations in the vertebral column. We repeatedly observe complete or partial absence of the supraoccipital bone and malformations of the exoccipital and the basioccipital bones. These results suggests a role for the <jats:italic>Hox\u20102.2<\/jats:italic> gene in specifying positional identity along the anterior\u2010posterior axis. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jez.1402640311","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T00:34:24Z","timestamp":1118450064000},"page":"323-336","source":"Crossref","is-referenced-by-count":42,"title":["Dominant mutation of the murine <i>Hox\u20102.2<\/i> gene results in developmental abnormalities"],"prefix":"10.1002","volume":"264","author":[{"given":"Satbir","family":"Kaur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gurparkash","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey L.","family":"Stock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire M.","family":"Schreiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann B.","family":"Kier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Yager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael L.","family":"Mucenski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"William J.","family":"Scott","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. 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