{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T11:57:56Z","timestamp":1780401476467,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,6,2]],"date-time":"2005-06-02T00:00:00Z","timestamp":1117670400000},"content-version":"vor","delay-in-days":4050,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1994,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>Ddc<\/jats:italic> cluster of genes on the left arm of chromosome 2 in <jats:italic>Drosophila<\/jats:italic> has been extensively characterized by Wright and coworkers (Wright, '87b). Many of the genes in the cluster are associated with the pigmentation and sclerotization of the cuticle, and at least 12 have been shown to play a role in female fertility. To characterize further the actions of genes in the cluster, we have investigated the effect on fertility of a total of five of the previously untested genes (<jats:italic>l(2)37Be, Bb, Bg, Bd<\/jats:italic>, and <jats:italic>Cg<\/jats:italic>), and three of the partially characterized genes (<jats:italic>l(2)37Ce, Ddc<\/jats:italic>, and <jats:italic>amd<\/jats:italic>). Each allele was crossed to <jats:italic>Df(2L)TW130 or<\/jats:italic><jats:sup><jats:italic>49h<\/jats:italic><\/jats:sup> flies in order to make it hemizygous over the 8\u201312 band deficiency covering the Ddc region, 37B9\u2010C1,2;37D1\u20102. Ovaries taken from larvae produced by this cross were transplanted into female larval hosts of <jats:italic>y f mal<\/jats:italic> genotype, that were then mated to <jats:italic>v f mal<\/jats:italic> males. The wild type allele of <jats:italic>mal<\/jats:italic> in implanted tissue allowed identification and study of surviving implants by staining for the presence of aldehyde oxidase. Of the 18 alleles available, <jats:italic>amd<\/jats:italic><jats:sup>H149<\/jats:sup>, <jats:italic>l(2)37Bb<\/jats:italic><jats:sup>1<\/jats:sup>, <jats:italic>Bb<\/jats:italic><jats:sup>9<\/jats:sup>, <jats:italic>Bb<\/jats:italic><jats:sup>11<\/jats:sup>, <jats:italic>Bd<\/jats:italic><jats:sup>6<\/jats:sup>, <jats:italic>Be<\/jats:italic><jats:sup>1<\/jats:sup>, <jats:italic>Bd<\/jats:italic><jats:sup>7<\/jats:sup>, <jats:italic>Be<\/jats:italic><jats:sup>2<\/jats:sup>, <jats:italic>Be<\/jats:italic><jats:sup>3<\/jats:sup>, <jats:italic>Ce<\/jats:italic><jats:sup>4<\/jats:sup>, and <jats:italic>Cg<\/jats:italic><jats:sup>1<\/jats:sup> did not allow enough growth to form transplantable ovaries; <jats:italic>l(2)37Bg<\/jats:italic><jats:sup>1<\/jats:sup>, <jats:italic>Bg<\/jats:italic><jats:sup>2<\/jats:sup>, and <jats:italic>Cg<\/jats:italic><jats:sup>tsl<\/jats:sup> prevented development of transplanted ovaries in their hosts; <jats:italic>l(2)37Ce<\/jats:italic><jats:sup>5<\/jats:sup> allowed implanted ovaries to attach to oviducts and grow, but insufficiently for production of eggs; and <jats:italic>Ddc<\/jats:italic><jats:sup>N27<\/jats:sup>, <jats:italic>amd<\/jats:italic><jats:sup>29<\/jats:sup>, and <jats:italic>l(2)37Bd<\/jats:italic><jats:sup>4<\/jats:sup> appeared not to restrict ovary development. Heteroallelic heterozygotes of Bd<jats:sup>7<\/jats:sup> \u00d7 Bd<jats:sup>4<\/jats:sup> also produced fully fertile ovaries, but no other heteroallelic combinations did so. No obvious correlation exists between this pattern of effects on ovarian fertility and the overall organization of the gene cluster. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jez.1402680607","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T02:37:47Z","timestamp":1118457467000},"page":"469-476","source":"Crossref","is-referenced-by-count":7,"title":["Effects of <i>Ddc<\/i> cluster lethal alleles on ovary growth, attachment, and egg production in <i>Drosophila<\/i>"],"prefix":"10.1002","volume":"268","author":[{"given":"Edward","family":"McCrady","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Tolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,2]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/genetics\/132.2.443","article-title":"Patterns of naturally occurring restriction map variation, dopa decarboxylase activity variation and linkage disequilibrium in the Ddc gene region of Drosophila melanogaster","volume":"132","author":"Aquadro C. 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