{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:21:19Z","timestamp":1773289279761,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,5,10]],"date-time":"2005-05-10T00:00:00Z","timestamp":1115683200000},"content-version":"vor","delay-in-days":3601,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Exp. Zool."],"published-print":{"date-parts":[[1995,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Homeobox\u2010containing genes may play an important role in establishing embryonic patterns during development of vertebrates. Retinoic acid is able to induce expression of Hox genes in cells in culture and to alter expression patterns in the developing vertebrate embryos. Using wholemount in situ hybridization, we have examined and compared the expression patterns of a homeobox\u2010containing gene, Msx\u20101, in early normal and vitamin A\u2010deficient quail embryos. At gastrulation stage, Msx\u20101 is primarily expressed in the posterior half of both normal and vitamin A\u2010deficient embryos. However, the gene is expressed wider and stronger in the vitamin A\u2010deficient embryos. At neurulation stages, Msx\u20101 is continuously expressed in the posterior region up to Hensen's node and in the edge of the neural fold in both normal and vitamin A\u2010deficient embryos. Notably, in the vitamin A\u2010deficient embryos, Msx\u20101 is expressed more strongly and is also expressed ectopically in the anterior and precardiac regions. These results provide evidence that endogenous retinoids are involved in the normal expression of Msx\u20101 in avian embryo and that the expression of Msx\u20101 is downregulated by endogenous and physiological retinoids in vivo during early avian embryogenesis. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jez.1402720408","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T00:57:13Z","timestamp":1118451433000},"page":"299-310","source":"Crossref","is-referenced-by-count":7,"title":["Comparative study of Msx\u20101 expression in early normal and vitamin A\u2010deficient avian embryos"],"prefix":"10.1002","volume":"272","author":[{"given":"Yiping","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Kostetskii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maija H.","family":"Zile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Solursh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,10]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"545","volume-title":"The Retinoids: Biology, Chemistry, and Medicine","author":"Armstrong R. 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