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We tested the capacity for embryos of the common wall lizard (<jats:italic>Podarcis muralis<\/jats:italic>) from low altitude to cope with low\u2010oxygen partial pressure (hypoxia) in an alpine environment. Developing embryos subjected to hypoxic atmospheric conditions (15\u201316% O<jats:sub>2<\/jats:sub>sea\u2010level equivalent) at 2,877\u00a0m above sea level exhibited responses common to vertebrates acclimatized to or evolutionarily adapted to high altitude: suppressed metabolism, cardiac hypertrophy, and hyperventilation. These responses might have contributed to the unaltered incubation duration and hatching success relative to the ancestral, low\u2010altitude, condition. Even so, hypoxia constrained egg energy utilization such that larger eggs produced hatchlings with relatively low mass. These findings highlight the role of physiological plasticity in maintaining fitness\u2010relevant phenotypes in high\u2010altitude environments, providing impetus to further explore altitudinal limits to ecological diversification in ectothermic vertebrates.<\/jats:p>","DOI":"10.1002\/jez.2115","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T07:03:19Z","timestamp":1508223799000},"page":"423-432","source":"Crossref","is-referenced-by-count":22,"title":["Physiological plasticity in lizard embryos exposed to high\u2010altitude hypoxia"],"prefix":"10.1002","volume":"327","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9137-1741","authenticated-orcid":false,"given":"Gerardo A.","family":"Cordero","sequence":"first","affiliation":[{"name":"Department of Biology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bea Angelica","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Biology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremie","family":"Souchet","sequence":"additional","affiliation":[{"name":"Station d'Ecologie Th\u00e9orique et Exp\u00e9rimentale du CNRS \u00e0 Moulis Moulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ga\u00eblle","family":"Micheli","sequence":"additional","affiliation":[{"name":"Station d'Ecologie Th\u00e9orique et Exp\u00e9rimentale du CNRS \u00e0 Moulis Moulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.A.","family":"Noble","sequence":"additional","affiliation":[{"name":"Ecology &amp; Evolution Research Centre School of Biological Earth and Environmental Sciences The University of New South Wales Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Gangloff","sequence":"additional","affiliation":[{"name":"Station d'Ecologie Th\u00e9orique et Exp\u00e9rimentale du CNRS \u00e0 Moulis Moulis France"},{"name":"Department of Ecology Evolution, and Organismal Biology Iowa State University Ames Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Uller","sequence":"additional","affiliation":[{"name":"Department of Biology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Aubret","sequence":"additional","affiliation":[{"name":"Station d'Ecologie Th\u00e9orique et Exp\u00e9rimentale du CNRS \u00e0 Moulis Moulis France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"15","volume-title":"Reptilian Incubation: Environment, Evolution, and Behaviour","author":"Ackerman R. 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