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The conditions of their underground burrows result in competition for oxygen consumption, yet despite this oxygen deprivation they emerge unscathed. To understand the mechanisms in place to facilitate neuronal preservation during hypoxia, we investigated the protein levels of well\u2010known cell\u2010stress factors. We found that under hypoxic conditions, nearly half of the proteins measured increased expression in brain, while only a few decreased. Under hypoxic conditions there appeared to be a HIF1\u03b1\u2010centered response, where HIF1\u03b1 and its interactors carbonic anhydrase 9, CITED2, p21\/CIP1, and NF\u03baB1, among others, were upregulated. Concurrently, a hypoxia\u2010induced decrease of cytochrome <jats:italic>c<\/jats:italic> was consistent with decreased mitochondrial function and protection from apoptosis. The picture that emerges is one of neuroprotection, cell\u2010cycle arrest, and the promotion of antiapoptotic functions, all of which are consistent with conserving energy and maintaining neural integrity under low oxygen levels. These results suggest how this species may be poised to face hypoxia and contribute to its remarkable ability to deal with myriad of other damaging factors and sets the stage for future work on the neuroprotective facilitators we identified.<\/jats:p>","DOI":"10.1002\/jez.2321","type":"journal-article","created":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T10:33:35Z","timestamp":1569234815000},"page":"571-576","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Naked mole rats activate neuroprotective proteins during hypoxia"],"prefix":"10.1002","volume":"331","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7052-7287","authenticated-orcid":false,"given":"Liam J.","family":"Hawkins","sequence":"first","affiliation":[{"name":"Department of Biology Carleton University Ottawa ON 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