{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T15:00:03Z","timestamp":1751468403603,"version":"3.37.3"},"reference-count":75,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T00:00:00Z","timestamp":1616716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["A.G.L. Doctoral Fellowship"],"award-info":[{"award-number":["A.G.L. Doctoral Fellowship"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exp Zool Pt A"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In many reptiles, digestion has been associated with the selection of higher body temperatures, the so\u2010called post\u2010prandial thermophilic response. This study aimed to investigate the excitation\u2013contraction (E\u2013C) coupling in postprandial broad\u2010snouted caimans (<jats:italic>Caiman latirostris<\/jats:italic>) in response to acute warming within a preferred body temperature range of crocodiles. Isometric preparations subjected to a temperature transition from 25\u00b0C to 30\u00b0C were used to investigate myocardial contractility of postprandial caimans, that is, 48\u2009h after the animals ingested a rodent meal corresponding to 15% of body mass. The caiman heart exhibits a negative force\u2013frequency relationship that is independent of the temperature. At 25\u00b0C, cardiac muscle was able to maintain a constant force up to 36\u2009bpm, above which it decreased significantly, reaching minimum values at the highest frequency of 84\u2009bpm. Moreover, E\u2013C coupling is predominantly dependent on transsarcolemmal Ca<jats:sup>2+<\/jats:sup> transport denoted by the lack of significant ryanodine effects on force generation. On the contrary, ventricular strips at 30\u00b0C were able to sustain the cardiac contractility at higher pacing frequencies (from 12 to 144\u2009bpm) due to an important role of Na<jats:sup>+<\/jats:sup>\/Ca<jats:sup>2+<\/jats:sup> exchanger in Ca<jats:sup>2+<\/jats:sup> cycling, as indicated by the decay of the post\u2010rest contraction, and a significant contribution of the sarcoplasmic reticulum above 72\u2009bpm. Our results demonstrated that the myocardium of postprandial caimans exhibits a significant degree of thermal plasticity of E\u2013C coupling during acute warming. Therefore, myocardial contractility can be maximized when postprandial broad\u2010snouted caimans select higher body temperatures (preferred temperature zone) following feeding.<\/jats:p>","DOI":"10.1002\/jez.2457","type":"journal-article","created":{"date-parts":[[2021,3,27]],"date-time":"2021-03-27T04:18:03Z","timestamp":1616818683000},"page":"417-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of change in temperature on the cardiac contractility of broad\u2010snouted caiman (<i>Caiman latirostris<\/i>) during digestion"],"prefix":"10.1002","volume":"335","author":[{"given":"Andr\u00e9 G.","family":"Lopes","sequence":"first","affiliation":[{"name":"Department of Physiological Sciences Federal University of Sa\u0303o Carlos  Sa\u0303o Carlos S\u00e3o Paulo Brazil"},{"name":"Joint Graduate Program in Physiological Sciences Federal University of Sa\u0303o Carlos\u2013UFSCar\/Sa\u0303o Paulo State University, UNESP Campus Araraquara  Araraquara S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1178-6673","authenticated-orcid":false,"given":"Diana A.","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences Federal University of Sa\u0303o Carlos  Sa\u0303o Carlos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L.","family":"Kalinin","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences Federal University of Sa\u0303o Carlos  Sa\u0303o Carlos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,26]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1242\/jeb.149.1.239","article-title":"Enhanced maximum frequency and force development of fish hearts following temperature acclimation","volume":"149","author":"Bailey J. R.","year":"1990","journal-title":"Journal of Experimental Biology"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1810-522X-53-9"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.248.3.H366"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-010-0658-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2828(90)91014-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0040-8166(84)90042-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.2036"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.88.4.437"},{"key":"e_1_2_8_10_1","first-page":"215","volume-title":"Handbook of Physiology. Vol. I: Comparative Physiology","author":"Burggren W.","year":"1997"},{"issue":"20","key":"e_1_2_8_11_1","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1242\/jeb.203.20.3117","article-title":"Effects of feeding on arterial blood gases in the American alligator Alligator mississippiensis","volume":"203","author":"Busk M.","year":"2000","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfb.12836"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2003.11.002"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4565(99)00109-6"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-9629(75)90369-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692936"},{"issue":"1","key":"e_1_2_8_17_1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1242\/jeb.140.1.227","article-title":"Differences in force\u2010frequency relationships and calcium dependency between elasmobranch and teleost hearts","volume":"140","author":"Driedzic W. R.","year":"1988","journal-title":"Journal of Experimental Biology"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1976.sp011247"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2001.281.3.C993"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobaz.2012.07.010"},{"issue":"7","key":"e_1_2_8_21_1","first-page":"2238","article-title":"Calcium release in skinned cardiac cells: Variations with species, tissues, and development","volume":"41","author":"Fabiato A.","year":"1982","journal-title":"Federation Proceedings"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1983.245.1.C1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1086\/524150"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1546-5098(08)60331-3"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a004242"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2001.1337"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00694-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.02228"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00381.2009"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2010.03.028"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1990.258.2.C274"},{"issue":"16","key":"e_1_2_8_32_1","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.1242\/jeb.203.16.2437","article-title":"Patterns of cardiovascular and ventilatory response to elevated metabolic states in the lizard Varanus exanthematicus","volume":"203","author":"Hicks J. W.","year":"2000","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.100.6.933"},{"key":"e_1_2_8_34_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1242\/jeb.167.1.47","article-title":"The influence of temperature on ryanodine sensitivity and the force\u2010frequency relationship in the myocardium of rainbow trout","volume":"167","author":"Hove\u2010Madsen L.","year":"1992","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692684"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.215335"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-93985-6_6"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-001-0237-9"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1139\/z92-168"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00714580"},{"issue":"1","key":"e_1_2_8_41_1","first-page":"71","article-title":"The ultrastructure of alligator conductive tissue: An electron microscopic study of the sino\u2010atrial node","volume":"69","author":"Koprla E. C.","year":"1987","journal-title":"Acta Physiologica Hungarica"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.2307\/1443728"},{"key":"e_1_2_8_43_1","doi-asserted-by":"crossref","first-page":"2491","DOI":"10.1242\/jeb.198.12.2491","article-title":"The length dependence of work production in rat papillary muscles in vitro","volume":"198","author":"Layland J.","year":"1995","journal-title":"Jounal Experimental Biology"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(99)00129-4"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504807200"},{"issue":"1","key":"e_1_2_8_46_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1242\/jeb.167.1.203","article-title":"Effect of season and temperature acclimation on the function of crucian carp (Carassius Carassius) heart","volume":"167","author":"Matikainen N.","year":"1992","journal-title":"Journal of Experimental Biology"},{"issue":"4","key":"e_1_2_8_47_1","first-page":"399","article-title":"Mechanisms underlying the genesis of post\u2010rest contractions in cardiac muscle","volume":"25","author":"Mill J. G.","year":"1992","journal-title":"Brazilian Journal of Medical and Biological Research"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2017.09.004"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(02)00841-6"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118849"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4565(97)00043-0"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-815872-2.00009-9"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2006.07.001"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2006.03.002"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-007-0166-3"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00587448"},{"issue":"2","key":"e_1_2_8_57_1","first-page":"43","article-title":"Distribution, habitats, and conservation of the caimans (Alligatoridae) of Paraguay","volume":"2","author":"Scott N. J.","year":"1990","journal-title":"Vida Silvestre Neotropical"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.023754"},{"issue":"16","key":"e_1_2_8_59_1","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/jeb.203.16.2447","article-title":"Ventilatory and cardiovascular responses of a python (Python molurus) to exercise and digestion","volume":"203","author":"Secor S. M.","year":"2000","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1994.266.4.G695"},{"key":"e_1_2_8_61_1","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1242\/jeb.200.11.1607","article-title":"The effect of temperature and adrenaline on the relative importance of the sarcoplasmic reticulum in contributing Ca2+ to force development in isolated ventricular trabeculae from rainbow trout","volume":"200","author":"Shiels H. A.","year":"1997","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_62_1","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1242\/jeb.202.7.881","article-title":"The sarcoplasmic reticulum plays a major role in isometric contraction in atrial muscle of yellowfin tuna","volume":"202","author":"Shiels H. A.","year":"1999","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00015.2014"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00050-8"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1810-522X-52-33"},{"issue":"2","key":"e_1_2_8_66_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1242\/jeb.204.2.325","article-title":"Structural flexibility of the intestine of Burmese python in response to feeding","volume":"204","author":"Starck J. M.","year":"2001","journal-title":"The Journal of Experimental Biology"},{"issue":"10","key":"e_1_2_8_67_1","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1242\/jeb.205.10.1377","article-title":"Structural flexibility of the small intestine and liver of garter snakes in response to feeding and fasting","volume":"205","author":"Starck J. M.","year":"2002","journal-title":"The Journal of Experimental Biology"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.000976"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1986.250.4.H654"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpb.2019.110371"},{"issue":"1","key":"e_1_2_8_71_1","first-page":"87","article-title":"Mechanical behavior of rest contractions in cardiac muscle","volume":"38","author":"Vassallo D. V.","year":"1988","journal-title":"Acta Physiologica Et Pharmacologica Latinoamericana: Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y De La Asociacion Latinoamericana De Farmacologia"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/0742-8413(89)90101-1"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00349.2001"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00051-X"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(02)00250-7"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00650.2009"}],"container-title":["Journal of Experimental Zoology Part A: Ecological and Integrative Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.2457","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jez.2457","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.2457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T03:35:23Z","timestamp":1693539323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.2457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,26]]},"references-count":75,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/jez.2457"],"URL":"https:\/\/doi.org\/10.1002\/jez.2457","archive":["Portico"],"relation":{},"ISSN":["2471-5638","2471-5646"],"issn-type":[{"type":"print","value":"2471-5638"},{"type":"electronic","value":"2471-5646"}],"subject":[],"published":{"date-parts":[[2021,3,26]]},"assertion":[{"value":"2021-01-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}