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We studied the effect of a thyroid inhibitor (ethylenethiourea\u00a0[ETU]) on metamorphosis and ovary development of three species, <jats:italic>Sphaerotheca pashchima, Indosylvirana caesari<\/jats:italic>, and <jats:italic>Euphlyctis cyanophlyctis<\/jats:italic> with different larval durations. We treated the tadpoles of these species with 50, 100, and 200\u2009mg\/L concentrations of ETU\u00a0and studied their larval duration, size at metamorphosis, and ovary development. The results revealed that ETU affects metamorphosis, depending on the species and concentration. ETU delayed metamorphosis of <jats:italic>E. cyanophlyctis<\/jats:italic> tadpoles and did not affect metamorphosis in <jats:italic>S. pashchima<\/jats:italic> tadpoles. Lower concentrations of ETU stimulated metamorphosis in <jats:italic>I. caesari<\/jats:italic> tadpoles while high concentration delayed metamorphosis. In the tadpoles (<jats:italic>E. cyanophlyctis<\/jats:italic>) treated with higher concentrations of ETU, ovary development was advanced with an increased size of the diplotene oocytes. Oocyte size was smaller in the tadpoles (of <jats:italic>I. caesari<\/jats:italic>) treated with lower concentrations of ETU. These results demonstrated that the tadpoles of these species show different responses to the thyroid inhibitor, possibly due to the differences in the larval duration and sensitivity. Inhibition or acceleration of metamorphosis did not interfere in the ovary development of <jats:italic>E. cyanophlyctis<\/jats:italic> and <jats:italic>I. caesari<\/jats:italic>. These results will be useful in understanding the impact of endocrine disruptors on the interaction between thyroid and sex steroid hormones.<\/jats:p>","DOI":"10.1002\/jez.2464","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T13:07:21Z","timestamp":1617887241000},"page":"469-476","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effect of ethylenethiourea on metamorphosis and ovary development: A comparative study of three larval frogs"],"prefix":"10.1002","volume":"335","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0393-9761","authenticated-orcid":false,"given":"Samadhan","family":"Phuge","sequence":"first","affiliation":[{"name":"Department of Zoology Savitribai Phule Pune University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Department of Zoology Savitribai Phule Pune University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radhakrishna","family":"Pandit","sequence":"additional","affiliation":[{"name":"Department of Zoology Savitribai Phule Pune University  Pune Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1400240303"},{"key":"e_1_2_8_3_1","volume-title":"AmphibiaWeb: Information on amphibian biology and conservation","author":"AmphibiaWeb","year":"2020"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2005.05049.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-019-7590-1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2007.01.005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390701613330"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.21085"},{"issue":"2","key":"e_1_2_8_9_1","first-page":"353","article-title":"Progress towards development of an amphibian\u2010based thyroid screening assay using Xenopus laevis. 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