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For nonruminants, corresponding data are lacking. Here, we report the effect of an increased food intake of a mixed diet in four domestic rabbit does due to lactation, and assess changes in particle size (as determined by wet sieving analysis) along the rabbit digestive tract. During lactation, rabbits achieved a distinctively higher dry matter intake than at maintenance, with a concomitant reduction in mean retention times of solute and particle markers, an increase in dry matter gut fill, a reduction in apparent digestibility of dry matter, and an overall increase in digestible dry matter intake. By contrast, there was no change in faecal mean particle size (mean \u00b1 SD: 0.58\u2009\u00b1\u20090.02 vs. 0.56\u2009\u00b1\u20090.01\u2009mm). A comparison of diet, stomach content and faecal mean particle size suggested that 98% of particle size reduction occurred due to ingestive mastication and 2% due to digestive processes. Very fine particles passing the finest sieve, putatively not only of dietary but mainly of microbial origin, were particularly concentrated in caecum contents, which corresponds to retention of microbes via a \u2018wash\u2010back' colonic separation mechanism, to concentrate them in caecotrophs that are re\u2010ingested. This study gives rise to the hypothesis that chewing efficiency on a consistent diet is not impaired by intake level in nonruminant mammals.<\/jats:p>","DOI":"10.1002\/jez.2505","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T06:18:25Z","timestamp":1626157105000},"page":"614-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Increasing food intake affects digesta retention, digestibility and gut fill but not chewing efficiency in domestic rabbits (<i>Oryctolagus cuniculus<\/i>)"],"prefix":"10.1002","volume":"335","author":[{"given":"Eva","family":"Findeisen","sequence":"first","affiliation":[{"name":"Institute of Animal Science, Animal Nutrition University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8147-1060","authenticated-orcid":false,"given":"Karl\u2010Heinz","family":"S\u00fcdekum","sequence":"additional","affiliation":[{"name":"Institute of Animal Science, Animal Nutrition University of Bonn  Bonn Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Fritz","sequence":"additional","affiliation":[{"name":"Zugspitzstr  Stockdorf Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-7745","authenticated-orcid":false,"given":"J\u00fcrgen","family":"Hummel","sequence":"additional","affiliation":[{"name":"Ruminant Nutrition, Department of Animal Sciences University of Goettingen  Goettingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3841-6207","authenticated-orcid":false,"given":"Marcus","family":"Clauss","sequence":"additional","affiliation":[{"name":"Clinic f\u00fcr Zoo Animals, Exotic Pets and Wildlife, Vetsuisse Faculty University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"volume-title":"Official methods and recommended practices of the American Oil Chemists' Society","year":"2009","author":"AOCS","key":"e_1_2_8_2_1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(94)77036-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03192594"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1079\/BJN19960139"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2019.104576"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1086\/physzool.63.4.30158172"},{"key":"e_1_2_8_8_1","first-page":"125","article-title":"Separation and delay of contents in the rabbit colon","volume":"2","author":"Bj\u00f6rnhag G.","year":"1972","journal-title":"Swedish Journal of Agricultural Research"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mmnz.19990750208"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952836904006077"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livprodsci.2005.05.019"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.12053"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0030-1299.2007.15461.x"},{"key":"e_1_2_8_14_1","first-page":"210","volume-title":"Nutritional ecology of herbivores","author":"Cork S. 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