{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:55:46Z","timestamp":1785930946568,"version":"3.56.0"},"reference-count":66,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exp Zool Pt A"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Melatonin (MEL) is an indole hormone synthesized and secreted by the pineal gland at night, which is involved in the regulation of body mass and thermogenesis in small mammals. To test the effects of exogenous MEL on body mass and thermogenic ability in two different red\u2010backed vole (<jats:italic>Eothenomys miletus<\/jats:italic>) populations from two different regions (Kunming [KM] and Dali [DL]) with different annual variation in climatic variables, such as temperature, sunshine and rainfall. we traced the changes of energy balance in <jats:italic>E. miletus<\/jats:italic> from KM\u00a0and DL, which were placed at 25\u2009\u00b1\u20091\u00b0C with photoperiod of 12\u2009L:12\u2009D, intraperitoneal injection of MEL was performed daily for 28 days. The results showed that body mass and food intake were significantly decreased, while resting metabolic rate (RMR) and nonshivering thermogenesis (NST) were significantly increased after MEL injection; Contents of total protein, mitochondrial protein, the activities of cytochrome C oxidase (COX) and \u03b1\u2010glycerophosphate oxidase (\u03b1\u2010PGO) in liver and brown adipose tissue (BAT) were enhanced; the activity of thyroxin 5\u2032\u2010deiodinase (T<jats:sub>4<\/jats:sub>5\u2032\u2010DII) and uncoupling protein 1 (UCP1) in BAT were also increased. Serum leptin, triiodothyronine (T<jats:sub>3<\/jats:sub>) levels and T<jats:sub>3<\/jats:sub>\/T<jats:sub>4<\/jats:sub> ratio were significantly increased, thyroxine (T<jats:sub>4<\/jats:sub>) levels was significantly decreased. Moreover, body mass and food intake in <jats:italic>E. miletus<\/jats:italic> from KM were higher than those from DL, but RMR and NST were lower than those from DL. Changes of body mass, food intake and thermogenic activity of KM were higher than those of DL when exposed to injection of MEL, indicating that <jats:italic>E. miletus<\/jats:italic> in KM were more sensitive to MEL. Furthermore, MEL was involved in the regulation of body mass and thermogenesis in <jats:italic>E. miletus<\/jats:italic> between KM and DL.<\/jats:p>","DOI":"10.1002\/jez.2680","type":"journal-article","created":{"date-parts":[[2023,1,18]],"date-time":"2023-01-18T06:16:59Z","timestamp":1674022619000},"page":"310-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effects of exogenous melatonin on body mass and thermogenesis in red\u2010backed vole (<i>Eothenomys miletus<\/i>) between Kunming and Dali regions"],"prefix":"10.1002","volume":"339","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7155-3233","authenticated-orcid":false,"given":"Hui\u2010Bao","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Ecological Adaptive Evolution and Conservation on Animals\u2010Plants in Southwest Mountain Ecosystem of Yunnan Province Higher Institutes College, School of Life Sciences Yunnan Normal University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Jia","sequence":"additional","affiliation":[{"name":"Yunnan College of Business Management  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng\u2010Kun","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ecological Adaptive Evolution and Conservation on Animals\u2010Plants in Southwest Mountain Ecosystem of Yunnan Province Higher Institutes College, School of Life Sciences Yunnan Normal University  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Long","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Ecological Adaptive Evolution and Conservation on Animals\u2010Plants in Southwest Mountain Ecosystem of Yunnan Province Higher Institutes College, School of Life Sciences Yunnan Normal University  Kunming China"},{"name":"Engineering Research Center of Sustainable Development and Utilization of Biomass Energy Ministry of Education  Kunming China"},{"name":"Key Laboratory of Yunnan Province for Biomass Energy and Environment Biotechnology  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9384(03)00215-4"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091646"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079x.1993.tb00903.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.257.1.R142"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-114-2-492"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(85)90415-9"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112798"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4565(93)90002-b"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00122"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod41.6.1004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00084"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12137"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.2.E372"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.3.R951"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00692753"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12472"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/27376"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.11.011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-9384(03)00081-7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/074873001129001980"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1095-6433(02)00041-7"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1095-6433(98)10030-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90549-1"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-020-00589-1"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/247224a0"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7233183"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079x.1985.tb00719.x"},{"key":"e_1_2_11_29_1","first-page":"21","article-title":"Melatonin induced thermogenesis in Brandt's voles (Microtus brandti)","volume":"44","author":"Hou J. 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