{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:46:09Z","timestamp":1791474369100,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,4,9]],"date-time":"2024-04-09T00:00:00Z","timestamp":1712620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exp Zool Pt A"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Type 1 diabetes stem\u2010cell\u2010based treatment approach is among the leading therapeutic strategies for treating cardiac damage owing to the stem cells' regeneration capabilities. Mesenchymal stem cells derived from adipose tissue (AD\u2010MSCs) have shown great potential in treating diabetic cardiomyopathy (DCM). Herein, we explored the antioxidant\u2010supporting role of N, N\u2032\u2010diphenyl\u20101,4\u2010phenylenediamine (DPPD) in enhancing the MSCs' therapeutic role in alleviating DCM complications in heart tissues of type 1 diabetic rats. Six male albinos Wistar rat groups have been designed into the control group, DPPD (250\u2009mg\/kg, i.p.) group, diabetic\u2010untreated group, and three diabetic rat groups treated with either AD\u2010MSCs (1\u2009\u00d7\u200910<jats:sup>6<\/jats:sup> cell\/rat, i.v.) or DPPD or both. Interestingly, all three treated diabetic groups exhibited a significant decrease in serum glucose, HbA1c, heart dysfunction markers (lactate dehydrogenase and CK\u2010MP) levels, and lipid profile fractions (except for HDL\u2010C), as well as some cardiac oxidative stress (OS) levels (MDA, AGEs, XO, and ROS). On the contrary, serum insulin, C\u2010peptide, and various cardiac antioxidant levels (GSH, GST, CAT, SOD, TAC, and HO\u20101), beside viable cardiac cells (G0\/G1%), were markedly elevated compared with the diabetic untreated group. In support of these findings, the histological assay reflected a marked enhancement in the cardiac tissues of all diabetic\u2010treated groups, with obvious excellency of the AD\u2010MSCs\u2009+\u2009DPPD diabetic\u2010treated group. Such results strongly suggested the great therapeutic potentiality of either DPPD or AD\u2010MSCs single injection in enhancing the cardiac function of diabetic rats, with a great noted enhancement superiority of DPPD and AD\u2010MSCs coadministration.<\/jats:p>","DOI":"10.1002\/jez.2810","type":"journal-article","created":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T03:05:44Z","timestamp":1712718344000},"page":"647-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Therapeutic effect of N, N\u2010Diphenyl\u20101,4\u2010phenylenediamine and adipose\u2010derived stem cells coadministration on diabetic cardiomyopathy in type 1 diabetes mellitus\u2010rat model"],"prefix":"10.1002","volume":"341","author":[{"given":"Hany M.","family":"Abd El\u2010lateef","sequence":"first","affiliation":[{"name":"Department of Chemistry, College of Science King Faisal University Al\u2010Ahsa Saudi Arabia"},{"name":"Chemistry Department, Faculty of Science Sohag University Sohag Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lashin S.","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Basic Medical Science, Faculty of Dentistry Al\u2010Ahliyya Amman University Amman Jordan"},{"name":"Physiology Department, Faculty of Medicine Mansoura University Mansours Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safa H.","family":"Qahl","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Science University of Jeddah Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalal N.","family":"Binjawhar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Princess Nourah bint Abdulrahman University Riyadh Saudi 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Shaimaa","family":"Shabana","sequence":"additional","affiliation":[{"name":"Fellow of Biochemistry, Genetic Unit, Children Hospital, Faculty of Medicine Mansoura University Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kholoud H.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Horus University in Egypt HUE Damietta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2228-0368","authenticated-orcid":false,"given":"Ibrahim","family":"Youssef","sequence":"additional","affiliation":[{"name":"Department of Chemistry, College of Science Mansoura University Mansoura Egypt"},{"name":"Neuroradiology and Neuro\u2010intervention Section, Department of Radiology UTSW Medical Center Dallas 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