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Two concentrations of TiO<jats:sub>2<\/jats:sub> NPs (25 and 150\u2009\u00b5g\/L) were used for 28 days. TiO<jats:sub>2<\/jats:sub> NPs bioaccumulation, gonadal weight, gonado\u2010somatic index, and histopathological alterations of gonads were determined. The tissues\u2019 accumulation of TiO2 NPs was concentration\u2010time\u2010dependent: it was 78.5\u2009\u00b1\u200928.93\u2009\u03bcg\/g dry weight in the exposed clams to 150\u2009\u00b5g\/L TiO<jats:sub>2<\/jats:sub> NPs after 4 weeks of exposure. The gonadal weight and gonado\u2010somatic index significantly decreased of the exposed group to 150\u2009\u00b5g\/L TiO<jats:sub>2<\/jats:sub> NPs over the experimental period that they ended with values (1.01\u2009\u00b1\u20090.57\u2009gm, 19.15\u2009\u00b1\u20097.75%, respectively). There are some histological alterations in the gonads of <jats:italic>C. nilotica<\/jats:italic> such as necrosis, deteriorated connective tissue, increased fibrous tissue, a reduced presence of mature sperms and mature ova, and irregular shapes of testicular\/ovarian follicles. When using Dimercaptosuccinic acid (DMSA), this led to a reduction in accumulation of TiO<jats:sub>2<\/jats:sub> NPs by the end of the experiment. So, <jats:italic>C. nilotica<\/jats:italic> is a promising model to reflect the adverse nano\u2010toxics. DMSA emerges as a potentially valuable chelating agent that abolishes the negative effects of these nanoparticles.<\/jats:p>","DOI":"10.1002\/jez.2848","type":"journal-article","created":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T04:44:07Z","timestamp":1721623447000},"page":"1053-1065","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The potential ameliorative role of Dimercaptosuccinic acid against the toxicity of Titanium Dioxide Nanoparticles on <i>Caelatura nilotica<\/i> clams"],"prefix":"10.1002","volume":"341","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7599-8077","authenticated-orcid":false,"given":"Hoda H.","family":"Abdel\u2011Azeem","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Sciences Menoufia University Shebeen El\u2010Koom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azza H.","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Sciences Menoufia University Shebeen El\u2010Koom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamalat Y.","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Sciences Menoufia University Shebeen El\u2010Koom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"AbdElhafez R.","family":"AbdElhafez","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Sciences Menoufia University Shebeen El\u2010Koom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0036-1514","authenticated-orcid":false,"given":"Sherin K.","family":"Sheir","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Sciences Menoufia University Shebeen El\u2010Koom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejar.2019.01.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-023-27666-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6904-9-16"},{"key":"e_1_2_10_5_1","unstructured":"Alhameed H. 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