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This current study aims to evaluate the impact of the treatment of olive leaf extract (OLE), bone marrow\u2010derived (BM\u2010MSCs), and their combination on hepatotoxicity in pregnant rats with diabetes. Methods: Animals were divided into five groups (10 pregnant rats each) as follows: control, GDM group, and OLE group (rats received streptozotocin (STZ) at a dose of 35\u2009mg\/kg body weight). GD\u2009+\u2009OLE set (pregnant rats were administered OLE at a dose of 200\u2009mg extract\/kg of body weight). GD\u2009+\u2009MSCs group (pregnant rats treated with MSCs). GD\u2009+\u2009OLE\u2009+\u2009MSCs group (pregnant rats were treated with both MSCs and OLE). Results: STZ induced significant changes in liver parameters, lipid profile, and oxidative stress. Treatment with OLE, BM\u2010MSCs, and their combination significantly ameliorated STZ\u2010induced liver damage and oxidative stress. STZ resulted in a significant change in liver parameters, lipid profile, and oxidative stress. OLE, BM\u2010MSC, and combination have significantly improved STZ\u2010induced deterioration in liver and improved oxidative stress. Conclusions: The findings demonstrate that OLE and BM\u2010MSCs have beneficial effects in mitigating diabetes\u2010related liver alterations. These outcomes showed that OLE and BM\u2010MSC have beneficial effects in alleviating diabetes\u2010related alterations in the liver.<\/jats:p>","DOI":"10.1002\/jez.2862","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T06:48:46Z","timestamp":1725518926000},"page":"25-34","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Mitigation of biochemical alterations in streptozotocin\u2010induced gestational diabetes in rats through mesenchymal stem cells and olive leaf extract"],"prefix":"10.1002","volume":"343","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6031-8799","authenticated-orcid":false,"given":"Mervat A.","family":"AbdRabou","sequence":"first","affiliation":[{"name":"Biology Department, College of Science Olive Research Center, Jouf University Sakaka Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed B. 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