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In the present work, we investigated the potential in vitro nematocidal effect of the aqueous extract of defense secretions for four species of marine mollusks: two cephalopods, namely the cuttlefish <jats:italic>Sepia pharaonis<\/jats:italic> and the common Octopus <jats:italic>Octopus vulagris<\/jats:italic> and two gastropods, the sea hare <jats:italic>Aplysia argus<\/jats:italic> and the sea slug <jats:italic>Berthillina citrina<\/jats:italic>, against the adult murine pinworm <jats:italic>Syphacia obvelata<\/jats:italic>. Data showed dose and time efficacy in all examined extracts. The sea slug's skin acid secretion has the highest impact, causing death in the cultivated worms, followed by the ink of the sea hare, the common octopus and the cuttlefish, where LC90 after 10\u2009h of exposure were 250, 290, 316, and 391\u2009\u00b5g\/mL, respectively. Comparatively with the control and albendazole\u2010treated groups, the skin acid secretion of the sea slug caused the highest levels of the antioxidant enzymes SOD, Cat and GSH\u2010PX; however, albendazole prompted the highest level of GSH\u2010PX enzyme in all experimental groups.<\/jats:p>","DOI":"10.1002\/jez.2877","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T10:17:01Z","timestamp":1730283421000},"page":"149-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nematicidal Potentiality of Four Marine Molluscans' Defensive Secretions From the Red Sea Against <i>Syphacia obvelata<\/i> (Nematoda: Oxyuridae) In Vitro"],"prefix":"10.1002","volume":"343","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1216-2635","authenticated-orcid":false,"given":"Nahla A.","family":"Radwan","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Science Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9742-2490","authenticated-orcid":false,"given":"Aalaa I.","family":"Atlam","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9249-4113","authenticated-orcid":false,"given":"Asmaa R.","family":"Abdel\u2010 Malek","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science Assuit University Asyut Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3383-3845","authenticated-orcid":false,"given":"Alaa Y.","family":"Moustafa","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,10,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-024-04399-0"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md18120657"},{"key":"e_1_2_9_4_1","volume-title":"Electron Microscopy: Microscopy: Principles and Techniques for Biologists","author":"Bozzola J. 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