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The venom of the <jats:italic>Leiurus quinquestratus<\/jats:italic> scorpion (LQV) has numerous medicinal uses. The purpose of this study was to conduct that LQV had an effect on <jats:italic>T. canis<\/jats:italic> larvae in the model of mice. Fifty male mice were divided into five groups (<jats:italic>n<\/jats:italic>\u2009=\u200910). Group 1 (Gp1) was the negative group, and from Gp2\u2010Gp5 had been infected with 800\u20131000\u2009<jats:italic>T. canis<\/jats:italic> embryonated eggs. Gp2 was left as positive control, Gp3 was orally administrated with albendazole (Alb) (100\u2009mg\/kg\/b.wt) for 7 consecutive days at first day post infection (pi), Gp4 was injected intra\u2010peritoneal (i.p) with LQV (0.03\u2009mg\/kg\/b.wt) for 15 consecutive days at the first day pi, and Gp5 was given Alb\/LQV in the same way and doses as Gp3 and Gp4. At the end of the experiment, at 30th pi, the blood samples were collected for evaluating the biochemical and hematological parameters. The larval count reduction in brain were evaluated, and the histopathological changes in brain and liver were detected. The results showed that, treatment with LQV or Alb\/LQV combinations significantly reduced the larval burden in the brain of the infected mice with reduction percentage reached to 70, and 72%, respectively. Interestingly, LQV and Alb\/LQV significantly reduced IL\u20104, IL\u201010, and TNF \u2013\u03b1 levels and increased IFN\u2010\u03b3 levels. Also, improved the liver transaminases activity, and ameliorated liver and brain architecture. Collectively, LQV may be a promising treatment for <jats:italic>T. canis<\/jats:italic> infection and albendazole alternative.<\/jats:p>","DOI":"10.1002\/jez.2893","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T11:32:31Z","timestamp":1735039951000},"page":"343-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Nematocidal Effect of <i>Leiurus quinquestratus<\/i> Scorpion Venom on <i>Toxocara canis<\/i> in Mice Model"],"prefix":"10.1002","volume":"343","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-5681","authenticated-orcid":false,"given":"Wesam M.","family":"Salama","sequence":"first","affiliation":[{"name":"Zoology Department, Faculty of Science Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rasha A.","family":"Elmahy","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Tanta University Tanta Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"343","article-title":"Efficacy of Mebendazole and Levamisole Alone or in Combination Against Intestinal Nematode Infections After Repeated Targeted Mebendazole Treatment in Zanzibar","volume":"81","author":"Albonico M.","year":"2003","journal-title":"Bulletin of the World Health Organization"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0065-308x(08)60151-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3923\/javaa.2012.2732.2736"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2023.103713"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00931514"},{"key":"e_1_2_10_7_1","first-page":"209","article-title":"Evaluation of Protective and Treatment of Thyme (Thymus vulgaris) Oil on T. vitulorum Infected Rats","volume":"6","author":"Amin M. 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