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This study aimed to evaluate physiological parameters of arrhythmogenesis in this species, by HR\u2010ECG and VCG techniques, under physical and pharmacological containment (ketamine\u2010xylazine and butorphanol). Materials and methods: Eight agouti in which the physiological parameters of arrhythmogenesis were evaluated by HR\u2010ECG and VCG techniques, under physical and pharmacological containment. We evaluated cardiac and pulmonary foci sounds, made femoral pulse inspection, body score analysis, gestational evaluation, echocardiographic examination, blood pressure measurement, and conventional electrocardiography. Results: The non\u2010sedated agoutis exhibited QRS duration of 93.25\u2009\u00b1\u20099.51, LAS\u2009&lt;\u200940 \u03bcV of 28.50\u2009\u00b1\u20094.65 and RMS of 93.50\u2009\u00b1\u200929.75. The value of QRS duration decreased in animals treated with ketamine\u2010xylazine and increased in those receiving butorphanol. The non\u2010sedated agoutis exhibited QRS duration of 93.25\u2009\u00b1\u20099.51, LAS\u2009&lt;\u200940 \u03bcV of 28.50\u2009\u00b1\u20094.65 and RMS of 93.50\u2009\u00b1\u200929.75. The value of QRS duration decreased in animals treated with ketamine\u2010xylazine and increased in those receiving butorphanol. The sedation protocols did not cause alterations for LAS\u2009&lt;\u200940 \u03bcV and RMS. The sQRST value in non\u2010sedated animals was 54.20\u00b0\u2009\u00b1\u200943.63 and the administration of ketamine\u2010xylazine increased this index to 102.87\u00b0\u2009\u00b1\u200953.57, while butorphanol did not induce alteration. The mean systolic, diastolic, and mean arterial pressures differed between physical and pharmacological restraints. Both pharmacological constraints reduced the blood pressure of the agoutis, analogously and mildly. Conclusion: The adoption of sedation protocols using the ketamine\u2010xylazine association and butorphanol did not interfere with HR\u2010ECG values and exhibited minimal VCG data and blood pressure changes.<\/jats:p>","DOI":"10.1002\/jez.2922","type":"journal-article","created":{"date-parts":[[2025,4,10]],"date-time":"2025-04-10T06:47:22Z","timestamp":1744267642000},"page":"693-702","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Butorphanol or a Combination of Ketamine and Xylazine Do Not Interfere With Arrhythmogenic Parameters in Agoutis (<i>Dasyprocta prymnolopha<\/i>) Obtained Through High\u2010Resolution Electrocardiogram"],"prefix":"10.1002","volume":"343","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9380-6596","authenticated-orcid":false,"given":"Charlys Rhands Coelho","family":"de Moura","sequence":"first","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-5689","authenticated-orcid":false,"given":"Herm\u00ednio Jos\u00e9","family":"da Rocha Neto","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3773-2590","authenticated-orcid":false,"given":"Regina Lucia","family":"dos Santos Silva","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0352-3964","authenticated-orcid":false,"given":"Nayla Maria","family":"da Silva Rezende Amorim","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Lindenberg Rocha","family":"Sarmento","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7319-9079","authenticated-orcid":false,"given":"Miguel Ferreira Cavalcante","family":"Filho","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-2281","authenticated-orcid":false,"given":"Wanderson Gabriel Gomes","family":"de Melo","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7662-2776","authenticated-orcid":false,"given":"Dayseanny","family":"de Oliveira Bezerra","sequence":"additional","affiliation":[{"name":"Advanced Campus of Jos\u00e9 de Freitas, Federal Institute of Education, Science and Technology of Piau\u00ed Jos\u00e9 de Freitas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8030-6067","authenticated-orcid":false,"given":"Maria Acelina Martins","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6218-6168","authenticated-orcid":false,"given":"Napole\u00e3o Martins Argolo","family":"Neto","sequence":"additional","affiliation":[{"name":"Federal University of Piau\u00ed, Ministro Petr\u00f4nio Portela University Campus (UFPI) Teresina Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,9]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"Andrade A. 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