{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T17:52:56Z","timestamp":1787593976066,"version":"build-2736575974"},"reference-count":89,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exp Zool Pt A"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Parkinson's disease (PD) is the second most common neurodegenerative disorder, marked by oxidative damage to dopaminergic neurons in the substantia nigra, resulting in motor and non\u2010motor symptoms. Antioxidant supplements have emerged as a potential therapeutic strategy, particularly for forms unresponsive to Levodopa. Due to the limitations of human studies, animal models, especially\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , have been widely used to investigate sporadic and familial PD. This systematic review and meta\u2010analysis aimed to evaluate the effectiveness of antioxidants in mitigating PD symptoms. We searched PubMed, Web of Science, and Google Scholar for studies published between 2000 and December 4, 2024, excluding reviews and irrelevant models or diseases. Methodological quality was assessed using the SYRCLE tool, and 82 studies met the inclusion criteria. A random\u2010effects model was applied using MetaEasy. Antioxidants such as terpenoids (effect size\u2009=\u20093.23), flavonoids (1.68), plant extracts (2.95), and others like vitamin C, melatonin, and Gastrodin (3.61) significantly improved PD outcomes. However, high heterogeneity across studies persisted. This variability may reflect differences in study design and execution. This heterogeneity may arise due to the methodological variations across studies. Our meta\u2010analysis highlighted the potential role of antioxidants in managing PD referring to key considerations for future research in this area.\n                  <\/jats:p>","DOI":"10.1002\/jez.70042","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:44:38Z","timestamp":1760003078000},"page":"85-104","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Antioxidants and Parkinson's Disease: A Systematic Review and Meta\u2010Analysis of Research Evidence and Prospectives Using the\n                    <i>Drosophila<\/i>\n                    Model"],"prefix":"10.1002","volume":"345","author":[{"given":"Mai","family":"Fathy","sequence":"first","affiliation":[{"name":"Zoology Department Faculty of Science, Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal","family":"Seif","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science, Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-7243","authenticated-orcid":false,"given":"Samar","family":"El Kholy","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science, Tanta University Tanta Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-08409-4"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu026"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2015.09.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2019-0136"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901010"},{"key":"e_1_2_10_7_1","first-page":"693","article-title":"EGb 761 Is a Neuroprotective Agent Against Beta\u2010Amyloid Toxicity","volume":"48","author":"Bastianetto S.","year":"2002","journal-title":"Cellular and Molecular Biology (Noisy\u2010le\u2010Grand, France)"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rmr.0000245461.90406.ad"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.39.110304.095804"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.3.4.12858"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2013.03.021"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2023.109615"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103843"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196902132800701"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2993-04.2004"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.04.034"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.22159\/ijpps.2017v9i11.19931"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130230"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00431"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-019-08562-6"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-016-9641-x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-483X(03)00158-6"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2019.04.047"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/35006074"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2021.109431"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2020.12.018"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfv099"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.112844"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081850"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c04312"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-009-9257-z"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1fo00847a"},{"key":"e_1_2_10_33_1","unstructured":"Higgins J. 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