{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:25:32Z","timestamp":1789647932553,"version":"4.0.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T00:00:00Z","timestamp":1229644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Exp Zool Pt B"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Scube1<\/jats:italic> encodes a secreted plasma membrane\u2010associated protein characterized by a N\u2010terminal signal peptide sequence, multiple EGF domains, a N\u2010linked glycosylated spacer region and a C\u2010terminal CUB region. Here, we describe expression of the mouse <jats:italic>Scube1<\/jats:italic> gene during early craniofacial development. Transcripts were identified in the nervous system, within the ventral neural tube, telencephalon and trigeminal ganglion. In addition, strong regionally restricted expression was found in the facial processes, including the medial and lateral nasal processes, maxilla and mandible, and caudal pharyngeal arches. During tooth development, <jats:italic>Scube1<\/jats:italic> localized to the dental papilla of both incisor and molar teeth. Together, these data suggest a potential role for <jats:italic>Scube1<\/jats:italic> during early craniofacial development. <jats:italic>J. Exp. Zool. (Mol. Dev. 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