{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:40:11Z","timestamp":1791322811789,"version":"4.3.1"},"reference-count":62,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,12,17]],"date-time":"2008-12-17T00:00:00Z","timestamp":1229472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Exp Zool Pt B"],"published-print":{"date-parts":[[2009,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Late tooth morphogenesis is characterized by a series of events that determine crown morphogenesis and the histodifferentiation of epithelial cells into enamel\u2010secreting ameloblasts and of mesenchymal cells into dentin\u2010secreting odontoblasts. Functional ameloblasts are tall, columnar, polarized cells that synthesize and secrete a number of enamel\u2010specific proteins. After depositing the full thickness of enamel matrix, ameloblasts shrink in size and regulate enamel maturation. Amelogenesis imperfecta (AI) is a heterogeneous group of inherited defects in enamel formation. Clinically, AI presents as a spectrum of enamel malformations that are categorized as hypoplastic, hypocalcified, or hypomaturation types, based upon the thickness and hardness of the enamel. The different types of AI are inherited, either as X\u2010linked, autosomal\u2010dominant, or autosomal\u2010recessive traits. Recently, several gene mutations have been identified to cause the subtypes of AI. How these genes, however, coordinate their function to control amelogenesis is not understood. In this review, we discuss the role of genes that play definitive role on the determination of ameloblast cell fate and life cycle based on studies in transgenic animals.\n                    <jats:italic>J. Exp. Zool. (Mol. Dev. Evol.) 312B:437\u2013444, 2009<\/jats:italic>\n                    . \u00a9 2008 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/jez.b.21261","type":"journal-article","created":{"date-parts":[[2008,12,19]],"date-time":"2008-12-19T08:44:10Z","timestamp":1229676250000},"page":"437-444","source":"Crossref","is-referenced-by-count":74,"title":["Molecular genetics of ameloblast cell lineage"],"prefix":"10.1002","volume":"312B","author":[{"given":"Marianna","family":"Bei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,12,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419069409004431"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0177(199712)210:4<383::AID-AJA3>3.0.CO;2-C"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2003.00843.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1242\/jcs.109.10.2509","article-title":"Laminin\u20105 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly","volume":"109","author":"Baker SE","year":"1996","journal-title":"J Cell Sci"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910408301204"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0909-8836.1998.eos106510.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20182"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.4.655"},{"key":"e_1_2_1_10_1","first-page":"255","article-title":"Developing teeth in epidermolysis bullosa hereditaria letalis. 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