{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:56:33Z","timestamp":1762865793985},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Exp Zool Pt B"],"published-print":{"date-parts":[[2011,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tooth eruption at the early postnatal period is strictly controlled by the molecules secreted mainly from follicular tissues, which recruit monocytes for osteoclast formation. In this study, it was hypothesized that different molecules can be expressed according to the stages of tooth eruption. Rat molar germs together with follicles were extracted and DD\u2010PCR was performed from the root formation stage 2nd molars germs (after eruptive movement) and cap stage 3rd molar germs (before movement) at postnatal day 9.<\/jats:p><jats:p>Cxcl\u201014, a potent chemoattractant, was detected as one of the differentially expressed molecules from DD\u2010PCR. Its expression increased significantly at the root formation stage, compared with the cap or crown formation stage at both transcription and translation levels. The expression patterns of cxcl\u201014 were consistent with those of MCP\u20101 and CSF\u20101, and opposite to OPG. Immunofluorescence showed that cxcl\u201014 was localized in the dental follicular tissues only at the root formation stage overlaying the proximo\u2010occlusal region of the molar germs. Many osteoclasts appeared on the surface of the alveolar bone which overlayed the occlusal region of the root formation stage 2nd molar germs and underwent resorption. Cxcl\u201014 expression was reduced considerably at both the translation and transcription levels by an alendronate treatment.<\/jats:p><jats:p>These results suggest that cxcl\u201014 may be implicated in the formation of the eruptive pathway of tooth germs via osteoclastogenesis. <jats:italic>J. Exp. Zool. (Mol. Dev. Evol.) 316:418\u2013426, 2011<\/jats:italic>. \u00a9 2011 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jez.b.21414","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T22:15:36Z","timestamp":1301696136000},"page":"418-426","source":"Crossref","is-referenced-by-count":7,"title":["Differential expression of cxcl\u201014 during eruptive movement of rat molar germs"],"prefix":"10.1002","volume":"316B","author":[{"given":"H. I.","family":"Yoo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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