{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T19:42:50Z","timestamp":1777491770363,"version":"3.51.4"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","award":["PIP 497"],"award-info":[{"award-number":["PIP 497"]}],"id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 510"],"award-info":[{"award-number":["PICT 510"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exp Zool Pt B"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Anuran larval development comprises tissues\/organs\/systems that are: exclusively of larvae, able to be remodelled, and those of postmetamorphic stages. Also, the anuran larval development is characterized by inter\u2010related parameters: time, size and shape forming part of growth and differentiation. The anuran metamorphosis starts when growth and differentiation achieve a threshold that differs among species since it is regulated by a number of external (environmental) and internal (hormonal) processes. Here we explore the consequences of exogenous disruptors on the thyroid gland (e.g., methimazole and thyroxine as T4) of three species by immersing premetamorphic tadpoles in predetermined concentrations of the disruptors for short periods (10 or 16 days). The species were\n                    <jats:italic>Pleurodema borellii, Leptodactylus chaquensis<\/jats:italic>\n                    , and\n                    <jats:italic>Dermatonotus muelleri<\/jats:italic>\n                    , which all breed in small temporary ponds during the summer, but differ in their ecomorphology. The experiments were conducted to evaluate the effects of these substances on larval development (based in Gosner larval stages), morphometric variation in body parameters (snout\u2010vent and total length by larval stages), and thyroid gland histopathology at the end of the assays. In\n                    <jats:italic>P. borelli<\/jats:italic>\n                    and\n                    <jats:italic>L. chaquensis<\/jats:italic>\n                    , methimazole produces significant increment of size measurements (nonparametric Kruskal\u2013Wallis,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u2009.05) during stages of digit differentiation and induced thyroid gland hypertrophy. In the three species, T4 exposure accelerated limb development and caused atrophy of thyroid gland. Prolonged T4 exposure in\n                    <jats:italic>L. chaquensis<\/jats:italic>\n                    and\n                    <jats:italic>D. muelleri<\/jats:italic>\n                    triggered metamorphic transformation in the gut and skull cartilages. Discussion about interspecific differences in responsiveness and sensitivity elucidates the importance of hormonal signals to morphological evolution.\n                  <\/jats:p>","DOI":"10.1002\/jez.b.22908","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T09:07:51Z","timestamp":1571130471000},"page":"279-293","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Differences in responsiveness and sensitivity to exogenous disruptors of the thyroid gland in three anuran species"],"prefix":"10.1002","volume":"332","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8037-797X","authenticated-orcid":false,"given":"Marissa","family":"Fabrezi","sequence":"first","affiliation":[{"name":"Instituto de Bio y Geociencias del NOA CCT CONICET Salta\u2010Jujuy  Salta Rep\u00fablica Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ver\u00f3nica Laura","family":"Lozano","sequence":"additional","affiliation":[{"name":"Instituto de Bio y Geociencias del NOA CCT CONICET Salta\u2010Jujuy  Salta Rep\u00fablica Argentina"},{"name":"Depto. Ecolog\u00eda, Gen\u00e9tica y Evoluci\u00f3n, Facultad de Ciencias Exactas y Naturales and Instituto de Ecolog\u00eda Gen\u00e9tica y Evoluci\u00f3n de Buenos Aires (IEGEBA) CONICET \u2013 Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C\u00e9sar","family":"Cruz","sequence":"additional","affiliation":[{"name":"Instituto de Bio y Geociencias del NOA CCT CONICET Salta\u2010Jujuy  Salta Rep\u00fablica Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2017.2784"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ede.12035"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874336601003020007"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.03.020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-142X.2005.05049.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2003.10.005"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1554"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1955"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.04.004"},{"key":"e_1_2_9_11_1","unstructured":"Cruz J. C.(2017). Cambios histomorfol\u00f3gicos en la gl\u00e1ndula tiroides durante la ontogenia dePseudis paradoxa(Anura Hylidae). Tesis Doctoral Universidad Nacional de Buenos Aires."},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi246"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/37.2.172"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385979-2.00007-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-455403-0.50015-3"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmor.1050590104"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11692-011-9128-5"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11692-014-9292-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1670\/11-194"},{"key":"e_1_2_9_20_1","first-page":"487","article-title":"Thyroid growth and its relationship to metamorphosis in Rana temporaria","volume":"16","author":"Fox H.","year":"1966","journal-title":"Journal of Embryology and Experimental Morphology"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/ede.12299"},{"key":"e_1_2_9_22_1","first-page":"183","article-title":"A simplified table for staging anurans embryos and larvae, with notes on identification","volume":"16","author":"Gosner K.","year":"1960","journal-title":"Herpetologica"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623309335063"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icn077"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.20136"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.131198998"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.1998.7111"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/37.2.146"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00307"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2010.0877"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2136755100"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009117"},{"key":"e_1_2_9_33_1","volume-title":"T\u00e9cnicas de histolog\u00eda animal","author":"Martoja R.","year":"1970"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7998.1974.tb03159.x"},{"key":"e_1_2_9_35_1","first-page":"47","article-title":"Estudio morfom\u00e9trico sobre el desarrollo y evoluci\u00f3n de las gl\u00e1ndulas tiroides durante la metamorfosis de Bufo arenarum","volume":"10","author":"Miranda L. A.","year":"1996","journal-title":"Cuadernos de Herpetolog\u00eda"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj083"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.2307\/2411661"},{"key":"e_1_2_9_38_1","doi-asserted-by":"crossref","first-page":"56611","DOI":"10.1038\/ncomms6661","article-title":"Evolutionary innovation and conservation in the embryonic derivation of the vertebrate skull","volume":"5","author":"Piekarski N.","year":"2014","journal-title":"Nature Communications"},{"key":"e_1_2_9_39_1","first-page":"785","article-title":"\u201cKin recognition\u201d among spadefoot toad tadpoles: A side\u2010effect of habitat selection","volume":"44","author":"Pfennig D. W.","year":"1990","journal-title":"Evolution"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00317349"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/joa.12897"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3663"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/icz041"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00287"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191361698"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41559-017-0268-6"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfx213"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.3109\/10520297609116684"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/icb\/37.2.124"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-6968-8_5"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15213"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00143"}],"container-title":["Journal of Experimental Zoology Part B: Molecular and Developmental Evolution"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjez.b.22908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.b.22908","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jez.b.22908","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jez.b.22908","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T19:47:52Z","timestamp":1694029672000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jez.b.22908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,15]]},"references-count":51,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1002\/jez.b.22908"],"URL":"https:\/\/doi.org\/10.1002\/jez.b.22908","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JEZ.B.22908\/v1\/decision1","asserted-by":"object"}]},"ISSN":["1552-5007","1552-5015"],"issn-type":[{"value":"1552-5007","type":"print"},{"value":"1552-5015","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,15]]},"assertion":[{"value":"2019-04-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}