{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T21:54:44Z","timestamp":1784757284354,"version":"3.55.0"},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T00:00:00Z","timestamp":1736553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012041","name":"Versus Arthritis","doi-asserted-by":"publisher","award":["18256"],"award-info":[{"award-number":["18256"]}],"id":[{"id":"10.13039\/501100012041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1120560"],"award-info":[{"award-number":["1120560"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018955","name":"Leeds Biomedical Research Centre","doi-asserted-by":"publisher","award":["NIHR203331"],"award-info":[{"award-number":["NIHR203331"]}],"id":[{"id":"10.13039\/501100018955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000777","name":"University of Leeds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000777","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Foot and Ankle Research"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Midfoot pain is common but poorly understood, with radiographs often indicating no anomalies. This study aimed to describe bone, joint and soft tissue changes and to explore associations between MRI\u2010detected abnormalities and clinical symptoms (pain and disability) in a group of adults with midfoot pain, but who were radiographically negative for osteoarthritis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Community\u2010based participants with midfoot pain underwent an MRI scan of one foot and scored semi\u2010quantitatively using the Foot OsteoArthritis MRI Score (FOAMRIS). Foot pain and disability were recorded using visual analog scales (VAS) and the Modified\u2010Manchester Foot Pain Disability Index (MMFPDI). Associations were assessed for continuous data using Spearman\u2019s Rho, and for categorical data, a Wilcoxon signed rank test. Linear regression was used to explore the association between participant\u2010reported measures and MRI abnormalities, adjusted for age, sex and BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010one participants (70% female, mean age 48.5\u00a0years, median BMI 28.6\u00a0kg\/m<jats:sup>2<\/jats:sup>) were included. Median VAS pain was 31\/100\u00a0mm (IQR 21\u201347) and median disability was 30\/48 (IQR 26\u201336). There was a moderate association between midfoot pain severity and the number of joints exhibiting joint space narrowing; adjusted results suggested 31% (95% confidence interval 3%\u201368%) worse VAS pain with each additional affected joint. Greater numbers of joints with cysts were associated with worse VAS pain [14% (0%\u201331%)] and disability [1.1 units (0\u20132.2)]. Effusion\/synovitis was associated with MMFPDI pain. No other MRI abnormalities were associated with sex, body mass and foot pain\/disability measures. Bone marrow lesions, joint space narrowing, cysts and osteophytes occurred more frequently with age. MRI abnormalities were common, particularly in the talo\u2010navicular joint, first and second cuneo\u2010metatarsal joints. Those with dorsal foot pain had more multi\u2010joint involvement, bone marrow lesions, joint space narrowing and cysts and for those with pain on midfoot movement, bone marrow lesions and cysts were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In people with midfoot pain, MRI\u2010detected features of osteoarthritis and soft\u2010tissue abnormalities were found, clustered in the medial and intermediate cuneiform joints. These features were more common with age but not associated with pain or disability measures. Younger people with dorsal midfoot pain exhibited early signs of bone and joint features of osteoarthritis and we recommend further imaging studies to determine the clinical and diagnostic significance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jfa2.70019","type":"journal-article","created":{"date-parts":[[2025,1,11]],"date-time":"2025-01-11T09:51:23Z","timestamp":1736589083000},"source":"Crossref","is-referenced-by-count":2,"title":["Association between clinical and MRI\u2010detected imaging findings for people with midfoot pain, a cross\u2010sectional study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9913-2569","authenticated-orcid":false,"given":"Jill","family":"Halstead","sequence":"first","affiliation":[{"name":"Leeds Community Healthcare NHS Trust  Leeds UK"},{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mart\u00edn\u2010Herv\u00e1s","sequence":"additional","affiliation":[{"name":"Radiology Department La Paz University Hospital Autonomous University of Madrid  Madrid Spain"},{"name":"Biomedical Research Networking Centre on Bioengineering Biomaterials and Nanomedicine  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M. A.","family":"Hensor","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"},{"name":"NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010Maree","family":"Keenan","sequence":"additional","affiliation":[{"name":"NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals Trust  Leeds UK"},{"name":"School of Healthcare University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G.","family":"Conaghan","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"},{"name":"NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals Trust  Leeds UK"},{"name":"Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis  Nottingham\/Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"McGonagle","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"},{"name":"NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals Trust  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John B.","family":"Arnold","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"},{"name":"NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals Trust  Leeds UK"},{"name":"Alliance for Research in Exercise, Nutrition &amp; Activity (ARENA) Allied Health &amp; Human Performance University of South Australia  Adelaide Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Jones","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Redmond","sequence":"additional","affiliation":[{"name":"Leeds Institute of Rheumatic and Musculoskeletal Medicine University of Leeds  Leeds UK"},{"name":"NIHR Leeds Biomedical Research Centre Leeds Teaching Hospitals Trust  Leeds UK"},{"name":"Centre for Sport, Exercise and Osteoarthritis Research Versus Arthritis  Nottingham\/Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075\u2010015\u20100693\u20103"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/glq203"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22677"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fas.2021.12.005"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.5114\/pjr.2020.99472"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.24.30958"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-023-10364-1"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24955"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/107110070302400704"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2009.11.010"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiomech.2003.10.007"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:qure.0000018499.64574.1f"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270004263995"},{"issue":"8","key":"e_1_2_11_15_1","first-page":"1550","article-title":"Visual Analog Scales in Formats Other Than a 10 Centimeter Horizontal Line to Assess Pain and Other Clinical Data","volume":"35","author":"Pincus T.","year":"2008","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304\u20103959(99)00263\u20108"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physio.2006.12.009"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.160617"},{"key":"e_1_2_11_19_1","volume-title":"An Atlas for the Foot Osteoarthritis Magnetic Resonance Imaging Score (FOAMRIS)","author":"Halstead J.","year":"2024"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.16.16626"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010007\u20100691\u20101"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kew335"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.07.011"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.12.022"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2015.06.010"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2020.02.439"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0176833"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2006.03.015"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis\u20102014\u2010205310"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102474\u201015\u2010276"}],"container-title":["Journal of Foot and Ankle Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jfa2.70019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T17:48:19Z","timestamp":1743270499000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jfa2.70019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,11]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/jfa2.70019"],"URL":"https:\/\/doi.org\/10.1002\/jfa2.70019","archive":["Portico"],"relation":{},"ISSN":["1757-1146","1757-1146"],"issn-type":[{"value":"1757-1146","type":"print"},{"value":"1757-1146","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,11]]},"article-number":"e70019"}}