{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:49:21Z","timestamp":1791866961292,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Foot and Ankle Research"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Charcot Neuroarthropathy (CN) is a progressive joint disorder resulting from peripheral neuropathy and repetitive microtrauma. Management prioritizes offloading to prevent deformity, ulceration, infection, and amputation. While three\u2010dimensional gait analysis can be useful for disease staging and guiding management, its cost and limited accessibility limit routine clinical use. This study evaluated plantar pressure and two\u2010dimensional gait kinematics in CN patients using a relatively low\u2010cost clinic\u2010based approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Following institutional review board approval, this cross\u2010sectional observational study was conducted at a single institution between July and December 2024. Nine patients with clinically diagnosed unilateral CN and 11 Healthy controls were enrolled. Participants walked at 1.0\u00a0mph on a treadmill wearing diabetic slippers equipped with insole pressure sensors and markers placed on standardized lower\u2010extremity landmarks. Peak plantar pressures were calculated for each step and averaged within predefined regions of interest (forefoot, metatarsals, midfoot, and hindfoot); median region\u2010specific values were used for group comparisons. The hip, knee, and ankle joint range of motion (ROM) were also assessed. Comparisons were made between affected and contralateral CN limbs, and between each of these limbs and Healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Affected limbs demonstrated significantly higher midfoot and significantly lower forefoot, hindfoot, and metatarsal plantar pressures than Healthy controls (Benjamini\u2010Hochberg adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 for all four regions). Knee ROM was significantly reduced in both affected and contralateral limbs compared with Healthy controls (adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.05 for both), whereas hip and ankle ROM did not differ significantly across groups. No affected\u2010versus\u2010contralateral differences survived correction for multiple comparisons in either plantar pressure or kinematic outcomes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CN participants exhibited reduced knee ROM and altered regional plantar pressures consistent with midfoot collapse, with reduced knee ROM also evident in the contralateral limb, supporting bilateral involvement in CN. These findings support the utility of clinic\u2010based integrated gait analysis as an adjunctive tool for characterizing CN and informing clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/jfa2.70224","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:39:46Z","timestamp":1791866386000},"source":"Crossref","is-referenced-by-count":0,"title":["Gait and Plantar Pressure Analysis in Charcot Neuroarthropathy: A Clinic\u2010Based Biomechanical Study"],"prefix":"10.1002","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-3350-4673","authenticated-orcid":false,"given":"Irene M.","family":"Laleye","sequence":"first","affiliation":[{"name":"Penn State College of Medicine Department of Orthopaedics and Rehabilitation The Pennsylvania State University  Hershey Pennsylvania 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Titus","family":"Richardson","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Department of Orthopaedics and Rehabilitation The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelby","family":"Alwine","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Department of Orthopaedics and Rehabilitation The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parker","family":"Fox","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Department of Orthopaedics and Rehabilitation The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashlee","family":"MacDonald","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Department of Orthopaedics and Rehabilitation The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Aynardi","sequence":"additional","affiliation":[{"name":"Penn State College of Medicine Department of Orthopaedics and Rehabilitation The Pennsylvania State University  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,12]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2020.100239"},{"key":"e_1_2_14_3_1","volume-title":"The Essentials of Charcot Neuroarthropathy: Biomechanics, Pathophysiology, and MRI Findings","author":"Pierre\u2010Jerome C.","year":"2022"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244\u2010019\u20100768\u20109"},{"key":"e_1_2_14_5_1","volume-title":"Biomechanics of Midfoot Charcot Neuroarthropathy in People 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