{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:12:41Z","timestamp":1783001561092,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,21]],"date-time":"2018-12-21T00:00:00Z","timestamp":1545350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["UM2013"],"award-info":[{"award-number":["UM2013"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","award":["\u20106374"],"award-info":[{"award-number":["\u20106374"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Genetic Counseling"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A nationwide pretest\u2013posttest study was conducted in all clinical genetic centres in the Netherlands, to evaluate the effects of an online decision aid to support persons who have a genetic predisposition to cancer and their partners in making an informed decision regarding reproductive options. Main outcomes (decisional conflict, knowledge, realistic expectations, level of deliberation, and decision self\u2010efficacy) were measured before use (T0), immediately after use (T1), and at 2\u00a0weeks (T2) after use of the decision aid. Paired sample <jats:italic>t<\/jats:italic> tests were used to compute differences between the first and subsequent measurements. T0\u2013T1 and T0\u2013T2 comparisons indicate a significant reduction in mean decisional conflict scores with stronger effects for participants with high baseline decisional conflict. Furthermore, use of the decision aid resulted in increased knowledge levels and improved realistic expectations. Level of deliberation only increased for participants with lower baseline levels of deliberation. Decision self\u2010efficacy increased for those with low baseline scores, whereas those with high baseline scores showed a reduction at T2. It can be concluded that use of the decision aid resulted in several positive outcomes indicative of informed decision\u2010making. The decision aid is an appropriate and highly appreciated tool to be used in addition to reproductive counseling.<\/jats:p>","DOI":"10.1002\/jgc4.1056","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T18:05:58Z","timestamp":1547143558000},"page":"533-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Online decision support for persons having a genetic predisposition to cancer and their partners during reproductive decision\u2010making"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3723-3281","authenticated-orcid":false,"given":"Kelly","family":"Reumkens","sequence":"first","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre+ Maastricht The Netherlands"},{"name":"GROW School for Oncology and Developmental Biology Maastricht University Medical Centre+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marly H. E.","family":"Tummers","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre+ Maastricht The Netherlands"},{"name":"GROW School for Oncology and Developmental Biology Maastricht University Medical Centre+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyce J. G.","family":"Gietel\u2010Habets","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre+ Maastricht The Netherlands"},{"name":"GROW School for Oncology and Developmental Biology Maastricht University Medical Centre+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander M. J.","family":"van Kuijk","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology and Medical Technology Assessment Maastricht University Medical Centre+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora M.","family":"Aalfs","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Academic Medical Centre Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christi J.","family":"van Asperen","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Leiden University Medical Center Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margreet G. E. M.","family":"Ausems","sequence":"additional","affiliation":[{"name":"Division of Biomedical Genetics, Department of Genetics University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margriet","family":"Coll\u00e9e","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Erasmus University Medical Center Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte J.","family":"Dommering","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics VU University Hospital Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Marleen","family":"Kets","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Radboud University Medical Center Nijmegen Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizet E.","family":"van der Kolk","sequence":"additional","affiliation":[{"name":"Family Cancer Clinic Netherlands Cancer Institute Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan C.","family":"Oosterwijk","sequence":"additional","affiliation":[{"name":"Department of Genetics Groningen University Medical Center, University of Groningen Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivianne C. G.","family":"Tjan\u2010Heijnen","sequence":"additional","affiliation":[{"name":"GROW School for Oncology and Developmental Biology Maastricht University Medical Centre+ Maastricht The Netherlands"},{"name":"Department of Medical Oncology Maastricht University Medical Centre+ Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trudy","family":"van der Weijden","sequence":"additional","affiliation":[{"name":"Department of Family Medicine, Faculty of Health, Medicine and Life Sciences, School CAPHRI Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine E. 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M.","family":"van Osch","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics Maastricht University Medical Centre+ Maastricht The Netherlands"},{"name":"Department of Health Promotion, Faculty of Health, Medicine and Life Sciences, School CAPHRI Maastricht University Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2013-101974"},{"key":"e_1_2_9_3_1","first-page":"189","volume-title":"Usability evaluation in industry","author":"Brooke J.","year":"1996"},{"issue":"3","key":"e_1_2_9_4_1","first-page":"13","article-title":"Validation of client decision\u2010making instruments in the context of psychiatry","volume":"28","author":"Bunn H.","year":"1996","journal-title":"The Canadian Journal of Nursing Research"},{"key":"e_1_2_9_5_1","volume-title":"StatLine: Bevolking; hoogstbehaald onderwijsniveau en onderwijsrichting","author":"CBS","year":"2016"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.1066"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/pon.3471"},{"issue":"3","key":"e_1_2_9_8_1","first-page":"304","article-title":"Reproductive options for prospective parents in families with Huntington\u2019s disease: Clinical, psychological and ethical reflections","volume":"19","author":"Die\u2010Smulders C.","year":"2013","journal-title":"Human Reproduction"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11019-011-9361-9"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu034"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01484.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/des441"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1369-7625.2009.00572.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6947-13-S2-S8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-017-0326-4"},{"issue":"3","key":"e_1_2_9_16_1","first-page":"588","article-title":"Awareness and attitude regarding reproductive options of persons carrying a BRCA mutation and their partners","volume":"32","author":"Gietel\u2010Habets J. 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